ArticleViruses2025
Clinical Characteristics of Paediatric RSV, Influenza, and SARS-CoV-2 Infections: Insights from Three Consecutive Seasons.
Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundThe purpose of this study was to retrospectively analyse the clinical presentation of RSV, Influenza, and SARS-CoV-2 infections in children across three consecutive seasons (2022/2023; 2023/2024; and 2024/2025).
methodsOf the 321 hospitalised patients, 129 (36%) tested positive for RSV, 110 (38%) for Influenza, and 82 (26%) for SARS-CoV-2. Children were aged ≤ 17 years (median: 15 months). The data were statistically analysed using the χ
resultsSignificant independent predictors of RSV infection were auscultatory abnormalities (OR: 15.9 [1.49-169]) and hospital admission ≥ 4 days after symptom onset (OR: 32.5 [1.19-907]). Among RSV-positive patients, compared with those aged < 6 months, those aged 7-24 months were more likely to present with higher CRP levels (OR 1.06 [1.003-1.13]), reduced appetite (OR 6.7 [1.62-27.67]), and longer duration of fever (OR 7.22 [1.47-35.59]), while in children > 24 months, only a longer duration of fever remained significant (OR 16.82 [2.14-162.4]). In Influenza, reduced appetite was the only characteristic feature in the 7-24-month age group (OR 13.55 [1.79-102.81]). In COVID-19, children aged 7-24 months more frequently had higher CRP levels (OR 1.108 [1.001-1.226]) and chronic diseases (OR 7.59 [1.115-51.64]), whereas in those >24 months, only CRP was significant (OR 1.16 [1.047-1.31]).
conclusionsRSV was associated with severe respiratory manifestations and later hospital admission, whereas Influenza and SARS-CoV-2 were characterised by milder courses with predominant upper respiratory symptoms. Observed age- and virus-specific patterns highlight the importance of continued surveillance and comparative research on major respiratory viruses in children.
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