Evidence map›Paper›PMID 41305420›Full record

SynthesisPathogens (Basel, Switzerland)2025

Systemic Soluble and Cellular Immune Response in Acute Rheumatic Fever and Rheumatic Heart Disease: A Systematic Review of Human Studies.

Ana Luiza da Silva Resende, Eula Graciele Amorim Neves, Brenda Martins Cavalcante, Walderez Ornelas Dutra

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Valve biology and rheumatic heart disease pathogenesis.Nature cardiovascular research · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ana Luiza da Silva ResendeLaboratório de Biologia das Interações Celulares, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida. Presidente Antônio Carlos, Pampulha, Belo Horizonte 6627, MG, Brazil.
Eula Graciele Amorim NevesLaboratório de Biologia das Interações Celulares, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida. Presidente Antônio Carlos, Pampulha, Belo Horizonte 6627, MG, Brazil.
Brenda Martins CavalcanteLaboratório de Biologia das Interações Celulares, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida. Presidente Antônio Carlos, Pampulha, Belo Horizonte 6627, MG, Brazil.
Walderez Ornelas DutraLaboratório de Biologia das Interações Celulares, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida. Presidente Antônio Carlos, Pampulha, Belo Horizonte 6627, MG, Brazil.ORCID 0000-0002-7586-9996

Funding

Leducq PRIMA Grant, CNPq, FAPEMIG, INCT-DT
6 · The paper itself

Abstract

Rheumatic heart disease (RHD) remains a major cause of preventable morbidity in low- and middle-income countries. As the most serious sequel of acute rheumatic fever (ARF) caused by

Indexed as

Immunity, CellularRheumatic FeverRheumatic Heart DiseaseCytokinesHumansStreptococcus pyogenesCytokinesacute rheumatic fevercellular immunityimmune-regulationimmunopathologyrheumatic heart disease

Identifiers

PMID41305420
PMCPMC12655604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.