ArticlePathogens (Basel, Switzerland)2025
Human Herpes Virus-Six Related Clinical and Functional Implications in Lung Transplant Patients: Bronco Alveolar Lavage Analysis, Coinfections, Rejection, and Survival.
Paolo Solidoro, Antonio Curtoni, Costanza Perotti, Camilla Perotti, Nour Shbaklo, Francesca Sidoti, Mauro Mangiapia, Francesco Giuseppe De Rosa, Silvia Corcione, Massimo Boffini and 3 more
Abstract read
In one paragraphArticle in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors.
Paolo SolidoroDivision of Respiratory Medicine, Cardiovascular and Thoracic Department, AOU Città Della Salute e Della Scienza di Torino, University of Turin, 10126 Torino, Italy.ORCID 0000-0003-3972-2871 Antonio CurtoniDivision of Virology, Department of Laboratory Medicine Public Health and Pediatrics, AOU Città Della Salute e Della Scienza di Torino, University of Turin, 10126 Torino, Italy.ORCID 0000-0001-8101-4196 Costanza PerottiDivision of Respiratory Medicine, Cardiovascular and Thoracic Department, AOU Città Della Salute e Della Scienza di Torino, University of Turin, 10126 Torino, Italy.
Camilla PerottiDepartment of Neurosciences, Rita Levi Montalcini, University of Turin, 10126 Torino, Italy.
Nour ShbakloMedical Sciences Department, University of Turin, 10126 Torino, Italy.
Francesca SidotiDivision of Virology, Department of Laboratory Medicine Public Health and Pediatrics, AOU Città Della Salute e Della Scienza di Torino, University of Turin, 10126 Torino, Italy.ORCID 0000-0001-5241-5273 Mauro MangiapiaDivision of Respiratory Medicine, Cardiovascular and Thoracic Department, AOU Città Della Salute e Della Scienza di Torino, University of Turin, 10126 Torino, Italy.
Francesco Giuseppe De RosaUnit of Infectious Diseases, Department of Medical Sciences, University of Turin, 10149 Torino, Italy.ORCID 0000-0001-8338-0130 Silvia CorcioneUnit of Infectious Diseases, Department of Medical Sciences, University of Turin, 10149 Torino, Italy.
Massimo BoffiniCardiac Surgery Division, Cardiovascular and Thoracic Department, AOU Città Della Salute e Della Scienza di Torino, 10124 Torino, Italy.
Matteo MarroCardiac Surgery Division, Cardiovascular and Thoracic Department, AOU Città Della Salute e Della Scienza di Torino, 10124 Torino, Italy.ORCID 0000-0002-4118-8930 Cristina CostaDivision of Virology, Department of Laboratory Medicine Public Health and Pediatrics, AOU Città Della Salute e Della Scienza di Torino, University of Turin, 10126 Torino, Italy.ORCID 0000-0002-6549-4553 Rocco Francesco RinaldoDivision of Respiratory Medicine, Cardiovascular and Thoracic Department, AOU Città Della Salute e Della Scienza di Torino, University of Turin, 10126 Torino, Italy.ORCID 0000-0003-3999-5298 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Human herpesvirus 6 (HHV-6) is a common virus that can reactivate in immunocompromised patients, including lung transplant (LT) recipients. This study aimed to evaluate the clinical and functional implications of HHV-6 infection in LT patients through a retrospective analysis of 175 individuals who underwent lung transplantation at the City of Health and Sciences of Turin between 2014 and 2023. Surveillance bronchoscopies-including bronchoalveolar lavage (BAL) and transbronchial biopsies-were performed at scheduled intervals over a two-year period to detect HHV-6 and other pathogens, and to assess acute rejection. Spirometries were performed to evaluate graft function. Among the cohort, 33% of 822 BAL samples tested were positive for HHV-6, with a notable association between high viral load (≥500 copies/mL) and the development of post-transplant lymphoproliferative disorder (PTLD) (13% vs. 1%,
Indexed as
CoinfectionGraft RejectionHerpesvirus 6, HumanLung TransplantationRoseolovirus InfectionsAdultAgedBronchoalveolar LavageBronchoalveolar Lavage FluidFemaleHumansMaleMiddle AgedRetrospective StudiesViral LoadBALepidemiologyhuman herpes virus 6infectionlung transplantation
Identifiers
PMID41305394
PMCPMC12655384
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