SynthesisPathogens (Basel, Switzerland)2025
Clinical Presentation, Management and Outcome of Cerebral Echinococcosis in Children: A Systematic Review and Meta-Analysis.
Synthesis in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Albendazole Monotherapy and Spleen Preservation in an Adolescent with Isolated Primary Splenic Cystic Echinococcosis: A Case Report.Pathogens (Basel, Switzerland) · 2026Article
- Isolated pontomedullary hydatid cyst presenting with progressive bulbar and long-tract dysfunction: a case report and literature review.BMC neurology · 2026Review
- Clinical and Radiological Features of a Large Intracranial Hydatid Cyst: A New Case Report.Case reports in infectious diseases · 2026Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCerebral echinococcosis is a rare, potentially serious parasitic disease in children, that can lead to intracranial hypertension, focal neurological deficits, seizures, and severe complications. We conducted a systematic review and meta-analysis on diagnostic, therapeutic approaches, and outcomes in pediatric cerebral echinococcosis.
methodsA systematic search was performed on PubMed, Scopus, and Web of Science, selecting English studies on children (0-18 years). Studies describing clinical, imaging, surgical, pharmacological, and outcome data were eligible. Statistical analyses (Fisher's exact and chi-square tests) were performed in R.
resultsA total of 100 studies with 462 pediatric patients met the inclusion criteria. High-resolution imaging has largely replaced invasive diagnostics; MRI-based diagnosis correlated with better outcomes. Headaches, vomiting, papilledema, seizures, and hemiparesis were common. Surgical cysts' removal remained the main therapy. Additional treatment with albendazole was associated with a higher probability of good outcome (
conclusionsAdvances in non-invasive imaging, refinement of surgical technique, and targeted antiparasitic therapy improved outcomes. Nevertheless, heterogeneous reporting and the prevailing paucity of evidence limit definitive recommendations. Prospective multicenter studies are needed to refine treatment and develop pediatric-specific guidelines.
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Registered trials
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