Evidence map›Paper›PMID 41305373›Full record

ArticlePathogens (Basel, Switzerland)2025

Diversity and Functional Predictions of Gut Microbiota in Vietnamese Children Aged 6-24 Months with Persistent Diarrhea of Unknown Etiology.

Thi Thanh Nga Pham, Trong Khoa Dao, Thi Viet Ha Nguyen, Thi Bich Thuy Phung, Hong Duong Nguyen, Thi Quy Nguyen, Thi Thu Hong Le, Thi Huyen Do

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thi Thanh Nga PhamVietnam National Children's Hospital, 879 La Thanh Street, Hanoi 11528, Vietnam.ORCID 0009-0004-2712-7842
Trong Khoa DaoInstitute of Biology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet Street, Hanoi 11307, Vietnam.ORCID 0000-0002-4501-3353
Thi Viet Ha NguyenVietnam National Children's Hospital, 879 La Thanh Street, Hanoi 11528, Vietnam.ORCID 0009-0000-5993-5837
Thi Bich Thuy PhungVietnam National Children's Hospital, 879 La Thanh Street, Hanoi 11528, Vietnam.ORCID 0009-0009-4846-6647
Hong Duong NguyenInstitute of Biology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet Street, Hanoi 11307, Vietnam.ORCID 0000-0001-8864-9303
Thi Quy NguyenInstitute of Biology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet Street, Hanoi 11307, Vietnam.ORCID 0000-0003-0462-3574
Thi Thu Hong LeInstitute of Biology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet Street, Hanoi 11307, Vietnam.ORCID 0000-0002-4383-5062
Thi Huyen DoInstitute of Biology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet Street, Hanoi 11307, Vietnam.ORCID 0000-0003-0412-8872

Funding

Ministry of Science and Technology ĐTĐLCN.63/22
6 · The paper itself

Abstract

Persistent diarrhea remains a significant cause of morbidity in young children, yet the role of gut microbiota has not been fully clarified. This prospective study evaluated the diversity and predicted functions of the gut microbiota in 30 children aged 6-24 months with persistent diarrhea of unknown etiology (patient group, PG) and 30 healthy controls (healthy group, HG). Nearly full-length 16S rRNA genes from fecal bacterial metagenomic DNA were sequenced and taxonomically annotated. Subsequently, all downstream analyses, including diversity assessment, differential abundance and functional prediction analyses, and data visualization, were performed using R software (version 4.5.0, 2025). The PG showed lower Shannon and higher Simpson indices than the HG (

Indexed as

BacteriaDiarrheaGastrointestinal MicrobiomeBiodiversityChild, PreschoolDNA, BacterialFecesFemaleHumansInfantMaleMetagenomicsProspective StudiesRNA, Ribosomal, 16SSoutheast Asian PeopleVietnamDNA, BacterialRNA, Ribosomal, 16S16S rRNA sequencingchildrendysbiosisfunctional predictiongut microbiotapersistent diarrhea

Identifiers

PMID41305373
PMCPMC12655197

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.