ReviewPathogens (Basel, Switzerland)2025
Bacterial Proteomics and Antibiotic Resistance Identification: Is Single-Cell Analysis a Worthwhile Pursuit?
Review in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Pushing the limits of single-cell proteomics to investigate bacterial heterogeneity using bacSCP.Nature communications · 2026Article
- Next-Generation Target Discovery in ESKAPE Pathogens: An AI-Driven Framework from Omics-Based to Systems-Level Modeling and Clinical Translation.Antibiotics (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotic resistance is a major threat to global public health. It is vital to understand the mechanism of antibiotic resistance development to prevent the emergence of new pan-resistant pathogenic bacteria and to develop new antibiotics. Measuring the differences in proteins among single bacterial cells can aid in identifying antibiotic resistance and antibiotic susceptibility due to their regulatory roles in bacterial physiology and homeostasis. Although single-cell proteomics has been successful in mammalian systems, attaining comparable performance in bacteria remains challenging due to the extremely limited proteome content of a single bacterial cell. This review discusses the role of proteomics analysis in determining antibiotic resistance and the various mass spectrometry-based strategies that have been successful in detecting protein biomarkers for antibiotic resistance from bulk proteomics analysis. It highlights the core challenges of bacterial single-cell proteomics in contrast to mammalian systems, explores emerging technologies, and the proteomes beyond the cells in studying antibiotic resistance development and antibiotic susceptibility testing.
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Registered trials
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