Evidence map›Paper›PMID 41305351›Full record

ArticlePathogens (Basel, Switzerland)2025

Challenges and Opportunities of Bacterial Vaccines as Alternatives to Antimicrobials in Swine Health Management: Insights from U.S. Veterinarians.

Xirui Zhang, Danqin Li, Michael D Apley, Locke Karriker, Joseph F Connor, Corinne Bromfield, Jordan T Gebhardt, Brian Lubbers, Hatem Kittana, Dustin Pendell and 7 more

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. AVeterinary sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xirui ZhangCenter on Biologics Development and Evaluation, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.
Danqin LiCenter on Biologics Development and Evaluation, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.
Michael D ApleyDepartment of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.
Locke KarrikerDepartment of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.ORCID 0000-0001-6003-1130
Joseph F ConnorCarthage Veterinary Service, LTD., Carthage, IL 62321, USA.
Corinne BromfieldCollege of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.
Jordan T GebhardtDepartment of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.ORCID 0000-0002-6144-6714
Brian LubbersDepartment of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.
Hatem KittanaDepartment of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.
Dustin PendellDepartment of Agricultural Economics, College of Agriculture, Kansas State University, Manhattan, KS 66506, USA.ORCID 0000-0002-4837-4330
Rachel MaderaCenter on Biologics Development and Evaluation, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.ORCID 0000-0002-6809-6956
Nina MuroCenter on Biologics Development and Evaluation, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.
Aidan CraigCenter on Biologics Development and Evaluation, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.
Brooke ShenkenbergCenter on Biologics Development and Evaluation, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.
Yuzhen LiCenter on Biologics Development and Evaluation, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.
Lihua WangCenter on Biologics Development and Evaluation, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.ORCID 0000-0001-7951-4175
Jishu ShiCenter on Biologics Development and Evaluation, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.ORCID 0000-0002-7177-9280

Funding

DHS 70RSAT19CB0000027National Bio and Agro-Defense Facility Transition Fund National Bio and Agro-Defense Facility Transition FundUSDA ARS Non-Assistance Cooperative Agreements 58-8064-8-011, 58-8064-9-007, 58-3020-9-020USDA National Institute of Food and Agriculture, Hatch-Multistate project 1021491USDA NIFA Subaward #25-6226-0633-002
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) is a significant global health concern, and the use of antibiotics in livestock, including swine production, is a major contributor. Vaccines offer a promising alternative for controlling bacterial infections in pigs, but their widespread use is often hindered by biological, economic, and practical challenges. This study surveyed U.S. swine veterinarians to identify which bacterial diseases require better vaccines and to understand the barriers to their adoption. Nineteen veterinarians with an average of 24.7 years of experience were surveyed across 21 states. The results identified

Indexed as

Bacterial InfectionsBacterial VaccinesSwine DiseasesVeterinariansAnimalsAnti-Bacterial AgentsHumansSurveys and QuestionnairesSwineUnited StatesAnti-Bacterial AgentsBacterial Vaccinesalternativesantimicrobial resistancebacterial vaccineschallengesopportunitiesswine healthveterinarians

Identifiers

PMID41305351
PMCPMC12655657

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.