Evidence map›Paper›PMID 41304949›Full record

ArticlePharmaceuticals (Basel, Switzerland)2025

Cytokine and Metabolomic Signatures of Mepolizumab Response Across Upper and Lower Airway Compartments in Severe Eosinophilic Asthma: An Exploratory Analysis.

Mauro Maniscalco, Pasquale Ambrosino, Claudio Candia, Antonino Di Stefano, Isabella Gnemmi, Martina Zappa, Nicolino Ambrosino, Dina Visca, Andrea Motta

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05063981 (Biomarkers Evaluation and Effect of Mepolizumab on Lower and Upper Airways Inflammation in Severe Refractory Eosinophilic Asthma), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05063981 completednot on this map

Biomarkers Evaluation and Effect of Mepolizumab on Lower and Upper Airways Inflammation in Severe Refractory Eosinophilic Asthma

TypeobservationalSponsorIstituti Clinici Scientifici Maugeri SpARan2021 to 2025Enrolled15ConditionsSevere Eosinophilic AsthmaArmsMepolizumab
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mauro ManiscalcoIstituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Telese Terme Institute, 82037 Telese Terme, Italy.ORCID 0000-0001-6751-9921
Pasquale AmbrosinoIstituti Clinici Scientifici Maugeri IRCCS, Scientific Directorate of Telese Terme Institute, 82037 Telese Terme, Italy.ORCID 0000-0002-9398-0428
Claudio CandiaDepartment of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, 90127 Palermo, Italy.
Antonino Di StefanoIstituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Veruno Institute, 28013 Gattico-Veruno, Italy.
Isabella GnemmiIstituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Veruno Institute, 28013 Gattico-Veruno, Italy.ORCID 0000-0003-0045-6369
Martina ZappaIstituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Tradate Institute, 21049 Tradate, Italy.ORCID 0000-0001-8443-5316
Nicolino AmbrosinoIstituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Montescano Institute, 27040 Montescano, Italy.
Dina ViscaIstituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Tradate Institute, 21049 Tradate, Italy.ORCID 0000-0003-2298-1623
Andrea MottaInstitute of Biomolecular Chemistry, National Research Council, 80078 Pozzuoli, Italy.ORCID 0000-0002-8643-658X

Funding

GlaxoSmithKline (Italy) N/A
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

asthmachronic diseasechronic respiratory diseasedisabilityexerciseinflammationmepolizumaboutcomeoxidative stressrehabilitation

Identifiers

PMID41304949
PMCPMC12655059

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.