Evidence map›Paper›PMID 41304945›Full record

ArticlePharmaceuticals (Basel, Switzerland)2025

Design, Synthesis, and Mechanistic Study of Novel Ciprofloxacin/Thiazole Chalcone Hybrids as Potential Anticancer Agents.

Hamada Hashem, Ali M Elshamsy, Safwat M Rabea, Adel A Marzouk, Stefan Bräse, Helal F Hetta, Abdullah Alkhammash, Ghallab Alotaibi, Hadeer M Farhan, Hossameldin A Aziz

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. NovelPharmaceuticals (Basel, Switzerland) · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hamada HashemDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt.ORCID 0000-0002-8649-7534
Ali M ElshamsyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, New Minia City 61768, Egypt.
Safwat M RabeaDepartment of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Adel A MarzoukNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA.ORCID 0000-0003-4864-2056
Stefan BräseInstitute of Biological and Chemical Systems Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Kaiserstrasse 12, 76131 Karlsruhe, Germany.ORCID 0000-0003-4845-3191
Helal F HettaDivision of Microbiology, Immunology and Biotechnology, Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0001-8541-7304
Abdullah AlkhammashDepartment of Pharmacology, College of Pharmacy, Shaqra University, Shaqra 11961, Saudi Arabia.ORCID 0009-0002-2000-2620
Ghallab AlotaibiDepartment of Pharmacology, College of Pharmacy, Shaqra University, Shaqra 11961, Saudi Arabia.
Hadeer M FarhanDepartment of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt.
Hossameldin A AzizDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, New Valley University, New Valley 72511, Egypt.ORCID 0009-0005-3165-3025

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel series of thiazole chalcone/ciprofloxacin hybrids were synthesized and screened for their anticancer activity against NCI-60 cancer cell lines, USA. Interestingly, compounds

Indexed as

anticancerapoptosisciprofloxacinmolecular dockingthiazole–chalconetopoisomerases I/II

Identifiers

PMID41304945
PMCPMC12655637

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.