Evidence map›Paper›PMID 41304924›Full record

ReviewPharmaceuticals (Basel, Switzerland)2025

Computational Chemistry Advances in the Development of PARP1 Inhibitors for Breast Cancer Therapy.

Charmy Twala, Penny Govender, Krishna Govender

Abstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Experimental and Mechanistic Validation of PARP1pred for Identifying Potent Leads.Computational and structural biotechnology journal · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Charmy TwalaDepartment of Chemical Sciences, Faculty of Science, University of Johannesburg, Doornfontein Campus, Johannesburg 2028, South Africa.ORCID 0000-0001-8731-7032
Penny GovenderDepartment of Chemical Sciences, Faculty of Science, University of Johannesburg, Doornfontein Campus, Johannesburg 2028, South Africa.ORCID 0000-0002-3011-6675
Krishna GovenderDepartment of Chemical Sciences, Faculty of Science, University of Johannesburg, Doornfontein Campus, Johannesburg 2028, South Africa.ORCID 0000-0002-9058-1675

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poly (ADP-ribose) polymerase 1 (PARP1) is an important enzyme that plays a central role in the DNA damage response, facilitating repair of single-stranded DNA breaks via the base excision repair (BER) pathway and thus genomic integrity. Its therapeutic relevance is compounded in breast cancer, particularly in

Indexed as

BRCA mutationsbreast cancercomputational chemistryDFTmachine learningMD simulationsmolecular dockingPARP1 inhibitionQSARsynthetic lethality

Identifiers

PMID41304924
PMCPMC12655458

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.