Evidence map›Paper›PMID 41304727›Full record

ReviewPharmaceutics2025

Green-Synthesized Nanomaterials from Edible and Medicinal Mushrooms: A Sustainable Strategy Against Antimicrobial Resistance.

Gréta Törős, Hassan El-Ramady, Duyen H H Nguyen, Walaa Alibrahem, Nihad Kharrat Helu, Reina Atieh, Arjun Muthu, Szintia Jevcsák, Dávid Semsey, Neama Abdalla and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gréta TörősInstitute of Animal Science, Biotechnology and Nature Conservation, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Böszörményi Street 138, 4032 Debrecen, Hungary.ORCID 0000-0003-1604-1985
Hassan El-RamadySoil and Water Department, Faculty of Agriculture, Kafrelsheikh University, Kafr El-Sheikh 33516, Egypt.ORCID 0000-0002-1113-726X
Duyen H H NguyenInstitute of Animal Science, Biotechnology and Nature Conservation, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Böszörményi Street 138, 4032 Debrecen, Hungary.ORCID 0000-0002-8450-2272
Walaa AlibrahemDoctoral School of Health Sciences, University of Debrecen, Egyetem Tér 1, 4028 Debrecen, Hungary.ORCID 0009-0006-4002-3217
Nihad Kharrat HeluDoctoral School of Health Sciences, University of Debrecen, Egyetem Tér 1, 4028 Debrecen, Hungary.ORCID 0009-0004-3459-0173
Reina AtiehDoctoral School of Nutrition and Food Science, University of Debrecen, Böszörményi Street 138, 4032 Debrecen, Hungary.ORCID 0009-0009-2931-7750
Arjun MuthuDoctoral School of Nutrition and Food Science, University of Debrecen, Böszörményi Street 138, 4032 Debrecen, Hungary.ORCID 0000-0001-5297-2811
Szintia JevcsákInstitute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, 138 Böszörményi Street, 4032 Debrecen, Hungary.ORCID 0009-0009-0624-6013
Dávid SemseyInstitute of Animal Science, Biotechnology and Nature Conservation, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Böszörményi Street 138, 4032 Debrecen, Hungary.
Neama AbdallaPlant Biotechnology Department, Biotechnology Research Institute, National Research Centre, 33 El Buhouth St., Dokki, Giza 12622, Egypt.ORCID 0000-0003-3847-1281
Tamer ElsakhawyMicrobiology Department, Soil, Water and Environment Research Institute, Sakha Agricultural Research Station, Agriculture Research Center, Kafr El-Sheikh 33717, Egypt.
Alexandra Florence TóthFaculty of Agricultural and Food Sciences and Environmental Management, Institute of Water and Environmental Management, University of Debrecen, Böszörményi Street 138, 4032 Debrecen, Hungary.ORCID 0000-0002-5123-2325
Péter Tamás NagyFaculty of Agricultural and Food Sciences and Environmental Management, Institute of Water and Environmental Management, University of Debrecen, Böszörményi Street 138, 4032 Debrecen, Hungary.ORCID 0000-0001-5883-0240
József ProkischInstitute of Animal Science, Biotechnology and Nature Conservation, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Böszörményi Street 138, 4032 Debrecen, Hungary.ORCID 0000-0002-1989-0600

Funding

the University of Debrecen Scientific Research Bridging Fund (DETKA)
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) poses an escalating global health crisis, projected to cause up to 10 million deaths annually by 2050. Conventional antibiotics are increasingly ineffective due to microbial adaptation, overuse, and disruption of gut microbiota. Nanotechnology offers promising alternatives, but traditional nanoparticle synthesis often relies on toxic chemicals and energy-intensive processes. This review explores mushroom-derived nanoparticles (myco-NPs) as sustainable, eco-friendly antimicrobials. Edible and medicinal mushrooms contain bioactive compounds, including polysaccharides, flavonoids, and proteins, that act as reducing and stabilizing agents in nanoparticle biosynthesis. Myco-NPs exhibit antimicrobial activity through membrane disruption, oxidative stress, immune modulation, and biofilm inhibition, while also demonstrating synergistic effects with antibiotics and potential roles in regulating the gut microbiota. Recent advances highlight their potential applications in medicine, food safety, and environmental protection. However, challenges remain regarding standardization, safety evaluation, and large-scale production. We emphasize interdisciplinary collaboration as essential to translating mushroom-based nanotechnology into effective clinical and industrial solutions.

Indexed as

antimicrobial resistancedrug deliveryedible mushroomsgreen synthesismyco-nanoparticlesnanocarriers

Identifiers

PMID41304727
PMCPMC12655374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.