ReviewPharmaceutics2025
Barrier Products for Topical Delivery-Insight into Efficacy Testing and Barrier-Boosting Compounds.
Review in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The barrier effect refers to the ability of a topical product to protect the tissue against environmental factors, restore epidermal barrier function, or alleviate complications upon chemoradiation therapy. The market of barrier products for topical delivery is experiencing increased growth, and novel barrier-boosting compounds are being developed. However, only scarce reports and limited evidence justify their barrier efficacy. This may be due to the lack of a standardized, robust method for testing the protective effect of topicals. The paper reviews the recent advances in clinical and experimental techniques on the barrier efficacy of topical products, emphasizing those with the highest standardization potential. The principles and applications of each approach are specified, and the factors affecting the research outcome are highlighted. For predictive results, it is advised to mix at least two methods that differ in the mode of barrier efficacy testing. Combining quantitative TEWL and qualitative permeability testing not only balances out the limitations of each technique but also helps build high-quality evidence on the barrier efficacy. This review also summarizes the novel barrier-boosting ingredients and recent topical formulation strategies for enhancing product barrier efficacy and restoring the epithelial barrier function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.