Evidence map›Paper›PMID 41304543›Full record

ArticleToxics2025

Maternal Exposure to 2,4-Di-tert-butylphenol During Pregnancy in a Mouse Model Leads to Abnormal Development of the Urinary System in Offspring.

Yuanyan Jiang, Ningli Ye, Minghui Yu, Haixin Ju, Chunyan Wang, Hengmin Wang, Jiaojiao Liu, Qian Shen, Hong Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuanyan JiangDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Ningli YeDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Minghui YuDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Haixin JuDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Chunyan WangDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Hengmin WangDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Jiaojiao LiuDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Qian ShenDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Hong XuDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The occurrence of congenital anomalies of the kidney and urinary tract (CAKUT) is influenced by intrauterine environmental factors, and maternal exposure to endocrine-disrupting chemicals (EDCs) during pregnancy may affect the kidney development of offspring. 2,4-Di-tert-butylphenol (2,4-DTBP) is a high-production volume chemical classified as an EDC, which has been detected in humans and has been found to increase mortality and malformation rates in zebrafish embryos. Its effects on mammalian development are still unknown. In this study, a maternal mouse model exposed to 2,4-DTBP throughout pregnancy was established by gavage. The overall conditions of the maternal mice and their offspring were observed, and the concentrations of 2,4-DTBP in maternal serum and offspring tissues were measured using liquid chromatography-tandem mass spectrometry. Exposure to 2,4-DTBP of 75 µg/g·day during pregnancy markedly reduced the early pregnancy rate in mice to 41.75% (95% CI: 33.53-49.97%;

Indexed as

2,4-DTBPCAKUTendocrine-disrupting chemicalshydronephrosislitter effectmaternal exposurematernal–fetal transferRXRαvesicoureteral reflux

Identifiers

PMID41304543
PMCPMC12656196

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.