Early Cell Adhesion of Periodontal Ligament Stem Cells on 3D Printed Polylactic Acid/Hydroxyapatite Scaffolds: An In Vitro Study.

Ildefonso Serrano-Belmonte, Javier Montero, Elena Guerrero-González, Alexandra Munteanu, Virginia Pérez-Fernández, Amparo Pérez-Silva, Ascensión Martínez-Cánovas

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Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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5 · Who and what money

Authors and funding

7 authors.

Ildefonso Serrano-BelmonteFaculty of Medicine, School of Dentistry, Clínica Odontológica Universitaria, 2 Planta, Hospital Morales Meseguer, University of Murcia, Avda. Marqués de los Vélez s/n, 30008 Murcia, Spain.ORCID 0000-0002-9623-1393

Javier MonteroDepartment of Surgery, Faculty of Medicine, University of Salamanca, 37008 Salamanca, Spain.ORCID 0000-0003-3936-6539

Elena Guerrero-GonzálezFaculty of Medicine, School of Dentistry, Clínica Odontológica Universitaria, 2 Planta, Hospital Morales Meseguer, University of Murcia, Avda. Marqués de los Vélez s/n, 30008 Murcia, Spain.

Alexandra MunteanuFaculty of Medicine, School of Dentistry, Clínica Odontológica Universitaria, 2 Planta, Hospital Morales Meseguer, University of Murcia, Avda. Marqués de los Vélez s/n, 30008 Murcia, Spain.

Virginia Pérez-FernándezDepartment of Social and Health Sciences, Institute of Biomedical Research (IMIB-Arrixaca), University of Murcia, 30120 Murcia, Spain.ORCID 0000-0003-1877-3055

Amparo Pérez-SilvaFaculty of Medicine, School of Dentistry, Clínica Odontológica Universitaria, 2 Planta, Hospital Morales Meseguer, University of Murcia, Avda. Marqués de los Vélez s/n, 30008 Murcia, Spain.ORCID 0000-0002-8621-3116

Ascensión Martínez-CánovasFaculty of Medicine, School of Dentistry, Clínica Odontológica Universitaria, 2 Planta, Hospital Morales Meseguer, University of Murcia, Avda. Marqués de los Vélez s/n, 30008 Murcia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polylactic acid (PLA) and its composites with hydroxyapatite (HA) have been studied in the field of bone repair applications. The objective of this study was to evaluate the biocompatibility of PLA/HA at different concentrations and to analyze early adhesion of periodontal ligament stem cells (PDLSCs). Cells were seeded in two 24-well plates, each containing six disk-shaped samples of PLA/HA (10%, 15% and 20%) and six control samples and then examined using scanning electron microscopy. Twelve 96-well plates were prepared with different elution concentrations (1/1, 1/2, 1/4, and 1/8) to assess biocompatibility using MTT cell viability and Hoechst 33342 assays at 24, 48, and 72 h. PLA/HA 20% showed the highest early adhesion (

Indexed as

additive manufacturingbiocompatibilitybone regenerationcell adhesionhydroxyapatitepolylactic acidscaffolds

Identifiers

PMID41304453

DOI10.3390/polym17223088

PMCPMC12656128

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.