Dietary Proline Supplementation Promotes Growth and Development in Weaned Foals by Modulating Gut Microbial Amino Acid Metabolism.

Chen Meng, Jianwen Wang, Yaqi Zeng, Xinkui Yao, Jun Meng

Abstract read

In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Nutrients · 2026
Trial

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chen MengCollege of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China.ORCID 0009-0008-6673-5874

Jianwen WangCollege of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China.ORCID 0000-0001-7148-4557

Yaqi ZengCollege of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China.ORCID 0009-0000-1881-1221

Xinkui YaoCollege of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China.

Jun MengCollege of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China.ORCID 0009-0004-4211-0870

Funding

Central government guides local science and technology development funds project: research on the mechanisms of horse breeding and exercise performance regulation ZYYD2025JD02Construction of equine milk probiotic library and R&D and demonstration of functional equine milk products 2024B02013-2Major Science and Technology Project of the Xinjiang Uygur Autonomous Region 2022A02013-1

6 · The paper itself

Abstract

This study investigated the effects of varying proline supplementation doses in weaned foals. Twenty-eight weaned foals (approximately 5 months of age; body weight: 54.45 ± 11.33 kg; with an equal number of males and females) were randomly assigned to one of four groups-a control group, a low-dose group (20 mg/kg·d), a medium-dose group (40 mg/kg·d), and a high-dose group (60 mg/kg·d)- receiving continuous supplementation for 60 days. Blood samples were collected periodically for the analysis of hormones, antioxidants, immune parameters, and plasma amino acids. Concurrently, fecal 16S rRNA sequencing was performed to assess the microbial community composition. We observed a significant time-dependent interaction between medium-to-high proline supplementation and time. Proline supplementation resulted in dose-dependent increases in foal body weight (

Indexed as

amino acid metabolismfecal microbiotaprolineweaning stressweanling foals

Identifiers

PMID41304282

DOI10.3390/microorganisms13112598

PMCPMC12654596

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.