ArticleMicroorganisms2025
Long-Term Epidemiology of Hepatitis B and Impact of Vaccination in the Autonomous Province of Vojvodina, Serbia: A Population-Based Study.
Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This retrospective population-based study aimed to update the epidemiology of hepatitis B in Vojvodina, Serbia, and assess the impact of vaccination on acute and chronic forms of the disease. Surveillance data from 1978 to 2024 were analyzed by period, age/sex, and geographic distribution. Joinpoint and Poisson regression analyses were used to evaluate long-term trends in hepatitis B incidence and mortality rates and the vaccine-coverage effects, respectively. A decreasing trend in both acute and chronic hepatitis B incidence and mortality was observed over the study period. The average incidence rate declined from 11.51/100,000 in the pre-immunization period (1978-1987) to 1.68/100,000 during the universal immunization period (2006-2024). For chronic hepatitis B, the average incidence rates were 2.27 and 2.62/100,000 in the periods 1997-2005 and 2006-2024, respectively. Uneven spatial distribution was noted across municipalities. Poisson regression analysis showed that for every 1% increase in infant vaccine coverage in the previous year, the incidence rates of acute and chronic hepatitis B decreased significantly by 2.20% and 1.80%, respectively. These findings support the sustained effectiveness of hepatitis B vaccination, particularly among children and adolescents, and underscore the importance of addressing subnational disparities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.