ArticleMicroorganisms2025
The Role of TLR3 rs3775291 Variant in West Nile Virus Infection: A Case-Control Study.
Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
West Nile virus (WNV) causes human disease with variable severity. Toll-like receptor 3 (TLR3) is essential for innate immune responses to viral infections, including WNV. The non-synonymous single-nucleotide polymorphism (SNP) rs3775291 (C/T), which alters TLR3 function, has been linked to susceptibility to several viral pathogens, but its role in WNV infection is unclear. This study investigates the association between rs3775291 and WNV infection in hospitalized patients. A case-control study was conducted in Cyprus, including 20 hospitalized WNV patients and 22 healthy controls (HCs). Genotyping was performed using a TaqMan allelic discrimination assay. The C/T genotype was significantly more frequent in WNV patients (65%) than in HCs (27.3%) (
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