Evidence map›Paper›PMID 41304107›Full record

ReviewMicroorganisms2025

Metabolic Engineering of Yeasts for the Production of the Triterpene Squalene: Current Status and Future Prospective.

Shasha Zuo, Xinjia Tan, Jiwei Mao, Fanglin Hu, Jiaxu Chen, Liusha Fan, Qiyuan Lu, Yifei Zhao, Yongtong Wang, Zhiqiang Xiao and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shasha ZuoLongping Branch, College of Biology, Hunan University, Changsha 410125, China.
Xinjia TanLongping Branch, College of Biology, Hunan University, Changsha 410125, China.
Jiwei MaoDepartment of Life Sciences, Chalmers University of Technology, SE41296 Gothenburg, Sweden.ORCID 0000-0001-6671-4143
Fanglin HuLongping Branch, College of Biology, Hunan University, Changsha 410125, China.
Jiaxu ChenHunan Institute of Agricultural Product Processing and Quality Safety, Dongting Laboratory, Hunan Academy of Agricultural Sciences, Changsha 410125, China.
Liusha FanLongping Branch, College of Biology, Hunan University, Changsha 410125, China.
Qiyuan LuLongping Branch, College of Biology, Hunan University, Changsha 410125, China.
Yifei ZhaoLongping Branch, College of Biology, Hunan University, Changsha 410125, China.
Yongtong WangLongping Branch, College of Biology, Hunan University, Changsha 410125, China.
Zhiqiang XiaoHunan Institute of Agricultural Product Processing and Quality Safety, Dongting Laboratory, Hunan Academy of Agricultural Sciences, Changsha 410125, China.
Siqi ZhangLongping Branch, College of Biology, Hunan University, Changsha 410125, China.
Yang ShanLongping Branch, College of Biology, Hunan University, Changsha 410125, China.
Juan LiuHunan Institute of Agricultural Product Processing and Quality Safety, Dongting Laboratory, Hunan Academy of Agricultural Sciences, Changsha 410125, China.
Fuhua FuLongping Branch, College of Biology, Hunan University, Changsha 410125, China.

Funding

Agricultural Science and Technology Innovation Fund of Hunan Province 2024CX02Changsha Municipal Natural Science Foundation kq2502098the Key Research Project of Dongting Laboratory 2024-DTZD-001the National Key Research and Development Program of China 2022YFD2100804
6 · The paper itself

Abstract

Squalene, a linear triterpene compound characterized by its distinctive isoprenoid backbone with six transisoprene units, is widely used in the medicinal, nutraceutical, and cosmetic industries. The escalating global demand for squalene, coupled with growing ethical concerns over shark-derived sources and the inherent limitations of plant extraction (low yield) and chemical synthesis (environmental burden), has propelled microbial biosynthesis as a sustainable alternative. While substantial progress has been made in elucidating the mevalonate pathway and regulatory mechanisms of squalene biosynthesis, achieving industrially viable titers through microbial platforms remains an unresolved challenge. This review systematically summarizes recent advances in squalene biosynthesis using yeast chassis, with a focus on metabolic engineering strategies implemented in

Indexed as

applicationmetabolic engineeringmicrobial synthesisSaccharomyces cerevisiaesqualeneYarrowia lipolytica

Identifiers

PMID41304107
PMCPMC12654689

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.