Evaluating the Clinical Efficacy of Membrane-Assisted Regenerative Therapy in Peri-Implantitis Management: A Comprehensive Review Incorporating Systematic Review Evidence.

Peri-implantitis (PI) is characterized by inflammatory tissue destruction and alveolar bone loss surrounding dental implants, posing clinical challenges. To promote bone regeneration, clinicians often use resorbable or non-resorbable membranes in combination with bone grafts or biologic agents. Despite their widespread application in PI management, the clinical efficacy of these approaches remains uncertain. Therefore, this study aims to evaluate the role of membrane-assisted regenerative therapy in the management of PI. A systematic literature search was conducted in PubMed, Scopus, Cochrane Library, and Google Scholar following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) guidelines, with the protocol registered in PROSPERO (CRD420251089276). Sixty-nine studies met the inclusion criteria. The primary outcomes assessed were bone-fill gain and reduction in probing pocket depth (PPD). Although some studies reported improved bone-fill and PPD reduction with membrane-assisted regenerative therapy, the findings were not consistently significant. Future research should validate the clinical efficacy of membranes through well-designed randomized trials and develop advanced decontamination techniques and implant surface modifications that could enhance treatment predictability and patient outcomes. Overall, while membranes show potential clinical value in regenerative therapy, their necessity remains uncertain owing to variability in the current evidence.