Evidence map›Paper›PMID 41303691›Full record

ArticleInternational journal of molecular sciences2025

Integrative Epigenomic and Targeted Protein Analysis in MRONJ: Correlating DNA Methylation with Bone Biomarkers.

Raed Awadh Alshammari, Marwa Tantawy, Danxin Wang, Elysse Castro-Hall, Maria Abreu, Alessandro Villa, Joseph Katz, Lexie Shannon Holliday, Yan Gong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Raed Awadh AlshammariDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.ORCID 0009-0006-5165-2190
Marwa TantawyDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.
Danxin WangDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-7134-3065
Elysse Castro-HallMiami Cancer Institute, Baptist Health South Florida, Miami, FL 33176, USA.
Maria AbreuMiami Cancer Institute, Baptist Health South Florida, Miami, FL 33176, USA.
Alessandro VillaMiami Cancer Institute, Baptist Health South Florida, Miami, FL 33176, USA.ORCID 0000-0002-1966-6000
Joseph KatzDepartment of Oral Medicine, College of Dentistry, University of Florida, Gainesville, FL 32610, USA.
Lexie Shannon HollidayDepartment of Orthodontics, College of Dentistry, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-0844-1965
Yan GongDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-8218-1620

Funding

Toward a Precision Medicine Approach to Medication-Related Osteonecrosis of the JawR56DE030538 · NIDCR · UNIVERSITY OF FLORIDA · PI GONG, YAN · 2021 to 2021
$337k
NIDCR NIH HHS R56 DE030538NIH HHS 1R56DE030538-01
6 · The paper itself

Abstract

Medication-related osteonecrosis of the jaw (MRONJ) is a severe adverse effect of antiresorptive agents, including bisphosphonates (BPs) and denosumab (DMB). We conducted a case-control epigenome-wide association study (EWAS) of 24 cancer patients treated with BPs or BPs + DMB using the Infinium

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawDNA MethylationEpigenomicsAgedBiomarkersBone and BonesBone Density Conservation AgentsCase-Control StudiesDenosumabDiphosphonatesEpigenesis, GeneticFemaleGenome-Wide Association StudyHumansMaleMiddle AgedBiomarkersBone Density Conservation AgentsDenosumabDiphosphonatesOsteocalcinbone proteins biomarkersbone remodelingDNA methylationepigeneticsepigenome-wide association study (EWAS)medication-related osteonecrosis of the jaw (MRONJ)

Identifiers

PMID41303691
PMCPMC12653879

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.