Evidence map›Paper›PMID 41303637›Full record

ArticleInternational journal of molecular sciences2025

Perinatal Ethanol Exposure Induces Astrogliosis and Decreases GRP55/PEA-Mediated Neuroprotection in Hippocampal Astrocytes of the 3×Tg Alzheimer's Animal Model.

Miguel Rodríguez-Pozo, Beatriz Pacheco-Sánchez, Meriem Ben Rabaa, Marialuisa de Ceglia, Sonia Melgar-Locatelli, Ignacio Santos, Fernando Rodríguez de Fonseca, Juan Suárez, Patricia Rivera

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Miguel Rodríguez-PozoInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29590 Málaga, Spain.ORCID 0009-0007-5276-6082
Beatriz Pacheco-SánchezInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29590 Málaga, Spain.ORCID 0000-0003-3058-0635
Meriem Ben RabaaInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29590 Málaga, Spain.
Marialuisa de CegliaInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29590 Málaga, Spain.ORCID 0000-0003-4256-7702
Sonia Melgar-LocatelliInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29590 Málaga, Spain.ORCID 0000-0001-6335-2685
Ignacio SantosDepartamento de Anatomía Humana, Medicina Legal e Historia de la Ciencia, Universidad de Málaga, 29010 Málaga, Spain.
Fernando Rodríguez de FonsecaInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29590 Málaga, Spain.ORCID 0000-0002-4516-5795
Juan SuárezInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29590 Málaga, Spain.ORCID 0000-0001-5254-9802
Patricia RiveraInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29590 Málaga, Spain.ORCID 0000-0002-0478-6667

Funding

Consejería de Universidad, Investigación e Innovación, Junta de Andalucía PI21/00291Instituto de Salud Carlos III CD24/00124MCIU/AEI/10.13039/501100011033 and the FSE+. RYC2023-044921-IMinisterio de Sanidad, Delegación de Gobierno para el Plan Nacional sobre Drogas 2020/048National System of Health, EU-ERDF-ISCIII. IFI21/00024Plataforma ISCIII de Dinamización e Innovación de las capacidades industriales del SNS y su transferencia efectiva al sector productivo PT23/00082Proyectos Desarrollo Tecnológico ISCIII DTS22/00021Proyectos Tractores Junta De Andalucia P18-TP-5194
6 · The paper itself

Abstract

Prenatal ethanol exposure (PEE) alters fetal brain development, potentially increasing the risk of neurodegenerative diseases such as Alzheimer's disease (AD) later in life. Although glial activation is implicated in AD pathology via cannabinoid and neuroinflammatory signaling, its potential response to PEE in the developing brain and its contribution to AD pathogenesis remain unknown. Using 3×Tg-AD offspring of both sexes born to mothers with PEE, we analyzed astrogliosis, inflammatory markers, and key components of cannabinoid and Ca

Indexed as

Alzheimer DiseaseAstrocytesEthanolGliosisHippocampusNeuroprotectionPrenatal Exposure Delayed EffectsAnimalsCells, CulturedDisease Models, AnimalFemaleMaleMiceMice, TransgenicPregnancyReceptors, CannabinoidEthanolReceptors, CannabinoidAlzheimer’s diseaseastrocytesendocannabinoid systemGPR55hippocampusinflammationlegal medicinetoxicology

Identifiers

PMID41303637
PMCPMC12652644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.