ArticleInternational journal of molecular sciences2025
β-Antithrombin Levels in Patients with Venous Thromboembolism.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Beta-antithrombin (β-AT), the isoform of antithrombin (AT) with a higher affinity for heparin, constitutes 5-10% of total AT in plasma. There are limited data regarding β-AT activity levels in thrombotic disorders. In our study, we analyzed samples from 200 non-AT-deficient patients who had experienced venous thromboembolism (VTE) compared to 200 healthy controls. Total AT activity was measured using a chromogenic anti-factor Xa assay. To measure β-AT, we used elevated NaCl (1.1 M) in the reagent to inhibit the heparin binding of α-AT. There were no significant differences in total AT activity (median (IQR)) levels between the control and VTE groups (100 (93-109)% and 99 (94-109)%, respectively;
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