Evidence map›Paper›PMID 41303585›Full record

ArticleInternational journal of molecular sciences2025

Nicotine-Induced VEGF Levels in NSCLC Cells Are Modulated by PKA, Hyaluronan, and p53.

Caroline Wozniak, Alvaro Cobos, Aya Sabri, Stuti Goel, Brooke Lopo, Sarah Sarofim, Chanidapa Chutipassakul, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Caroline WozniakChemistry Department, Eastern Michigan University, Ypsilanti, MI 48197, USA.
Alvaro CobosChemistry Department, Eastern Michigan University, Ypsilanti, MI 48197, USA.
Aya SabriChemistry Department, Eastern Michigan University, Ypsilanti, MI 48197, USA.
Stuti GoelChemistry Department, Eastern Michigan University, Ypsilanti, MI 48197, USA.
Brooke LopoChemistry Department, Eastern Michigan University, Ypsilanti, MI 48197, USA.
Sarah SarofimChemistry Department, Eastern Michigan University, Ypsilanti, MI 48197, USA.
Chanidapa ChutipassakulChemistry Department, Eastern Michigan University, Ypsilanti, MI 48197, USA.
Jeffrey GuthrieChemistry Department, Eastern Michigan University, Ypsilanti, MI 48197, USA.ORCID 0009-0009-4329-7901
Deborah HeylChemistry Department, Eastern Michigan University, Ypsilanti, MI 48197, USA.
Hedeel Guy EvansChemistry Department, Eastern Michigan University, Ypsilanti, MI 48197, USA.ORCID 0000-0002-7970-9084

Funding

Probing the Role of Insulin-Like Growth Factor-Binding Protein 3 and Humanin in Regulating Hyaluronan FunctionR15GM131222 · NIGMS · EASTERN MICHIGAN UNIVERSITY · PI GUY EVANS, HEDEEL I. · 2019 to 2025
$1.5M
NIGMS NIH HHS R15 GM131222NIH HHS 2R15GM131222-03
6 · The paper itself

Abstract

Nicotine promotes non-small cell lung cancer (NSCLC) survival in part by elevating vascular endothelial growth factor (VEGF), yet the upstream regulatory mechanisms remain unclear. Here we identify a PKA-HA-p53 regulatory axis that governs nicotine-driven VEGF levels and survival in A549 (p53

Indexed as

Carcinoma, Non-Small-Cell LungCyclic AMP-Dependent Protein KinasesHyaluronic AcidLung NeoplasmsNicotineTumor Suppressor Protein p53Vascular Endothelial Growth Factor AA549 CellsCell Line, TumorCell SurvivalHumansHyaluronan ReceptorsSignal TransductionCyclic AMP-Dependent Protein KinasesHyaluronan ReceptorsHyaluronic AcidNicotineTP53 protein, humanTumor Suppressor Protein p53Vascular Endothelial Growth Factor AVEGFA protein, humancaspase-3extracellularhyaluronan (HA)nicotineNSCLCp53propranololprotein kinase A (PKA)VEGFα-bungarotoxin

Identifiers

PMID41303585
PMCPMC12652776

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.