Evidence map›Paper›PMID 41303511›Full record

ArticleInternational journal of molecular sciences2025

TDP-43 Regulates Rab4 Levels to Support Synaptic Vesicle Recycling and Neuromuscular Connectivity in

Monsurat Gbadamosi, Giulia Romano, Michela Simbula, Giulia Canarutto, Linda Ottoboni, Stefania Corti, Fabian Feiguin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Loss of TDP-43 Drives Innate Immune Activation Through Relish inInternational journal of molecular sciences · 2026
    Article
  2. TDP-43: [GU]-ardian of the transcriptome.Molecular neurodegeneration · 2026
    Review
  3. Neuronal Calcium Signaling and Cytoskeletal Dynamics in Neurodegeneration.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Monsurat GbadamosiInternational Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149 Trieste, Italy.
Giulia RomanoInternational Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149 Trieste, Italy.ORCID 0000-0003-0356-4947
Michela SimbulaInstitute for Genetic and Biomedical Research, The National Research Council (CNR), 09042 Cagliari, Italy.
Giulia CanaruttoInternational Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149 Trieste, Italy.ORCID 0000-0001-5010-7269
Linda OttoboniDino Ferrari Center, Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy.ORCID 0000-0001-5412-7785
Stefania CortiDino Ferrari Center, Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy.ORCID 0000-0001-5425-969X
Fabian FeiguinDepartment of Life and Environmental Sciences, University of Cagliari, 09042 Monserrato, Italy.ORCID 0000-0002-8486-7546

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathological loss of nuclear TDP-43 is a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), leading to extensive alterations in RNA metabolism and a broad number of neuronal transcripts. However, the key effectors linking TDP-43 dysfunction to synaptic defects remain unclear. In this study, using

Indexed as

Amyotrophic Lateral SclerosisDNA-Binding ProteinsDrosophila ProteinsNeuromuscular Junctionrab4 GTP-Binding ProteinsSynaptic VesiclesAnimalsDisease Models, AnimalDrosophilaDrosophila melanogasterHumansInduced Pluripotent Stem CellsMicrotubule-Associated ProteinsMotor NeuronsDNA-Binding ProteinsDrosophila Proteinsfutsch protein, Drosophilamicrotubule-associated protein 1BMicrotubule-Associated Proteinsrab4 GTP-Binding ProteinsTARDBP protein, humanALSDrosophilaendosomal traffickingFTDMAP1BNMJsRab4synaptic vesicleTDP-43

Identifiers

PMID41303511
PMCPMC12652574

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.