Evidence map›Paper›PMID 41303507›Full record

ReviewInternational journal of molecular sciences2025

MTHFD2: A Retrospective and a Glance into the Future.

Costas Koufaris, Vicky Nicolaidou

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Costas KoufarisCyprus Cancer Research Institute, Nicosia 2109, Cyprus.ORCID 0000-0002-1222-5130
Vicky NicolaidouDepartment of Life Sciences, School of Life and Health Sciences, University of Nicosia, Nicosia 2417, Cyprus.ORCID 0000-0003-1017-2677

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 1985 confirmation by Mejia and MacKenzie of mammalian NAD-dependent methylenetetrahydrofolate dehydrogenase activity launched four decades of research on methylenetetrahydrofolate dehydrogenase (NAD

Indexed as

AminohydrolasesMethylenetetrahydrofolate Dehydrogenase (NADP)Minor Histocompatibility AntigensMultifunctional EnzymesAnimalsFolic AcidHumansNeoplasmsOxidation-ReductionAminohydrolasesFolic AcidMethylenetetrahydrofolate Dehydrogenase (NADP)Minor Histocompatibility AntigensMTHFD2 protein, humanMultifunctional EnzymesMTHFD2one-carbon metabolismretrospective

Identifiers

PMID41303507
PMCPMC12651984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.