Evidence map›Paper›PMID 41303492›Full record

ArticleInternational journal of molecular sciences2025

Identification of Novel Metabolic Signatures on Human Gut Microbiota: Ellagic Acid, Naringenin, and Phloroglucinol.

Adriana C S Pais, Tânia B Ribeiro, Ezequiel R Coscueta, Maria Manuela Pintado, Armando J D Silvestre, Sónia A O Santos

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Adriana C S PaisCICECO-Aveiro Institute of Materials, Chemistry Department, University of Aveiro, Camous de Santiago, 3810-193 Aveiro, Portugal.ORCID 0000-0002-0974-4853
Tânia B RibeiroUniversidade Católica Portuguesa, CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.
Ezequiel R CoscuetaUniversidade Católica Portuguesa, CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.ORCID 0000-0003-4496-2001
Maria Manuela PintadoUniversidade Católica Portuguesa, CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.ORCID 0000-0002-0760-3184
Armando J D SilvestreCICECO-Aveiro Institute of Materials, Chemistry Department, University of Aveiro, Camous de Santiago, 3810-193 Aveiro, Portugal.ORCID 0000-0001-5403-8416
Sónia A O SantosCICECO-Aveiro Institute of Materials, Chemistry Department, University of Aveiro, Camous de Santiago, 3810-193 Aveiro, Portugal.ORCID 0000-0002-6749-7619

Funding

Fundação para a Ciência e Tecnologia 2021.03348.CEECINDFundação para a Ciência e Tecnologia LA/P/0006/2020Fundação para a Ciência e Tecnologia SFRH/BD/143348/2019Fundação para a Ciência e Tecnologia UIDB/50011/2020Fundação para a Ciência e Tecnologia UIDB/50016/2020Fundação para a Ciência e Tecnologia UIDP/50011/2020
6 · The paper itself

Abstract

Phenolic compounds are widely known for their beneficial effects on human health. However, it is essential to understand which low molecular weight metabolites are produced by the gut microbiota, when non-absorbed compounds reach the colon, and whether these metabolites are more biologically active than their precursors. In this context, this study aims to explore the gut microbiota metabolites of relevant phenolic compounds commonly found in the human diet. Therefore, ellagic acid, naringenin, and phloroglucinol were incubated with human feces for 48 h, and the ensuing metabolites were analyzed by ultra-high-performance liquid chromatography with diode array detector coupled to ion trap mass spectrometry (UHPLC-DAD-MS

Indexed as

Ellagic AcidFlavanonesGastrointestinal MicrobiomeMetabolomePhloroglucinolChromatography, High Pressure LiquidFecesGas Chromatography-Mass SpectrometryHumansMaleEllagic AcidFlavanonesnaringeninPhloroglucinolellagic acidfecal fermentationhuman gut microbiotametabolitesnaringeninphenolic compoundsphloroglucinol

Identifiers

PMID41303492
PMCPMC12652937

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.