Evidence map›Paper›PMID 41303476›Full record

ArticleInternational journal of molecular sciences2025

Coordinated Biosynthesis of Essential Cell Envelope Components: Lipopolysaccharide and Fatty Acids Requires LapD, Acyl Carrier Protein, and Fully Hexaacylated Lipid A.

Marta Jeschke, Aravind Ayyolath, Akshay Maniyeri, Satish Raina, Gracjana Klein

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Essential Role of LapD in the Absence of Cardiolipins.International journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marta JeschkeLaboratory of Bacteria Genetics, Gdansk University of Technology, 80-233 Gdansk, Poland.
Aravind AyyolathLaboratory of Bacteria Genetics, Gdansk University of Technology, 80-233 Gdansk, Poland.
Akshay ManiyeriLaboratory of Bacteria Genetics, Gdansk University of Technology, 80-233 Gdansk, Poland.
Satish RainaLaboratory of Bacteria Genetics, Gdansk University of Technology, 80-233 Gdansk, Poland.ORCID 0000-0003-3175-4932
Gracjana KleinLaboratory of Bacteria Genetics, Gdansk University of Technology, 80-233 Gdansk, Poland.ORCID 0000-0001-8695-8065

Funding

National Science Centre 2023/49/B/NZ1/01986
6 · The paper itself

Abstract

Lipopolysaccharide (LPS) is an essential component of the outer membrane (OM) of Gram-negative bacteria, and its levels are tightly co-regulated with phospholipid (PL) amounts. This homeostatic regulation necessitates the involvement of numerous genes, including

Indexed as

Acyl Carrier ProteinFatty AcidsLipid ALipopolysaccharidesCell WallEscherichia coliAcyl Carrier ProteinFatty AcidsLipid ALipopolysaccharidesacetyl-CoA carboxylasefatty acid biosynthesis FASIIheptosyltransferaseLapBLapDlipopolysaccharide (LPS)myristoyltransferasephospholipids

Identifiers

PMID41303476
PMCPMC12652820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.