Multiple Defects in Muscle Regeneration in the HSALR Mouse Model of RNA Toxicity.

Ramesh S Yadava, Mira A Zineddin, Mani S Mahadevan

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ramesh S YadavaDepartment of Pathology, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0002-0092-5033

Mira A ZineddinDepartment of Pathology, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0002-6741-2777

Mani S MahadevanDepartment of Pathology, University of Virginia, Charlottesville, VA 22908, USA.

Funding

The role of TGFβs and cFAPs in Cardiac Pathology from RNA ToxicityR01HL169790 · NHLBI · UNIVERSITY OF VIRGINIA · PI Ramesh Yadava · 2023 to 2026

$3.2M

RNA Toxicity and Muscle RegenerationR01AR071170 · NIAMS · UNIVERSITY OF VIRGINIA · PI MAHADEVAN, MANI SUBRAMANIAM · 2017 to 2021

$2.0M

National Heart Lung and Blood Institute 1R01HL169790National Heart Lung and Blood Institute 1R56HL162953National institute of Arthritis and Musculoskeletal and Skin Disease 1R01AR071170NHLBI NIH HHS R01 HL169790NIAMS NIH HHS R01 AR071170

6 · The paper itself

Abstract

Myotonic dystrophy type 1 (DM1) results from the toxicity of RNA produced from the mutant allele of the DMPK gene. The mechanism by which the toxic RNA causes muscular dystrophy in DM1 is unknown. Dystrophy in DM1 is associated with defective muscle regeneration and repair. Here, we used the BaCl

Indexed as

Muscle, SkeletalMyotonic DystrophyMyotonin-Protein KinaseRegenerationRNAAnimalsDisease Models, AnimalMiceMuscle Fibers, SkeletalSatellite Cells, Skeletal MuscleDMPK protein, mouseMyotonin-Protein KinaseRNAfiber typemuscle regenerationmuscular dystrophymyotonic dystrophyRNA toxicitysatellite cells

Identifiers

PMID41303468

DOI10.3390/ijms262210985

PMCPMC12651964

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.