Evidence map›Paper›PMID 41303458›Full record

ArticleInternational journal of molecular sciences2025

Pregnenolone Bioproduction in Engineered Methylobacteria: Design and Elaboration.

Daria Tekucheva, Veronika Poshekhontseva, Dmitry Fedorov, Mikhail Karpov, Ludmila Novikova, Alexey Zamalutdinov, Marina Donova

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daria TekuchevaG.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms (IBPM), Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Prospekt Nauki 5, Pushchino, Moscow 142290, Russia.ORCID 0000-0003-4780-0905
Veronika PoshekhontsevaG.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms (IBPM), Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Prospekt Nauki 5, Pushchino, Moscow 142290, Russia.ORCID 0000-0002-3415-1929
Dmitry FedorovG.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms (IBPM), Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Prospekt Nauki 5, Pushchino, Moscow 142290, Russia.ORCID 0000-0001-7338-7929
Mikhail KarpovG.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms (IBPM), Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Prospekt Nauki 5, Pushchino, Moscow 142290, Russia.ORCID 0000-0002-9162-7196
Ludmila NovikovaBelozersky Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Leninskie Gory 1/40, Moscow 119991, Russia.ORCID 0009-0009-1563-5723
Alexey ZamalutdinovG.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms (IBPM), Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Prospekt Nauki 5, Pushchino, Moscow 142290, Russia.ORCID 0000-0001-7524-8877
Marina DonovaG.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms (IBPM), Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Prospekt Nauki 5, Pushchino, Moscow 142290, Russia.ORCID 0000-0002-9917-8428

Funding

Ministry of Science and Higher Education of the Russian Federation 122040500054-3Ministry of Science and Higher Education of the Russian Federation 125041005029-5
6 · The paper itself

Abstract

In this study, for the first time, the genes encoding the mammalian steroidogenesis system-cytochrome P450scc (CYP11A1), and its native redox partners adrenodoxin and adrenodoxin reductase-were successfully expressed in the methylobacterium

Indexed as

Metabolic EngineeringMethylobacteriumPregnenoloneAdrenodoxinCholesterolCholesterol Side-Chain Cleavage EnzymeFerredoxin-NADP ReductaseAdrenodoxinCholesterolCholesterol Side-Chain Cleavage EnzymeFerredoxin-NADP ReductasePregnenolonecholesterolcytochrome P450scc (CYP11A1)heterologous expressionmethylobacteriaMethylorubrum extorquenspregnenolone

Identifiers

PMID41303458
PMCPMC12652760

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.