ArticleInternational journal of molecular sciences2025
From Plankton to Primates: How VSP Sequence Diversity Shapes Voltage Sensing.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Voltage-sensing phosphatases (VSPs) provide a conserved framework for dissecting the mechanics of voltage sensing and for engineering genetically encoded voltage indicators (GEVIs). To evaluate how natural sequence diversity shapes function, we compared VSP voltage-sensing domains (VSDs) from multiple species by replacing the phosphatase domain with a fluorescent protein to enable optical detection of VSD responses. Every construct that reached the plasma membrane produced a voltage-dependent optical signal, underscoring the deep conservation of voltage sensing across VSP orthologs. Yet lineage-specific substitutions generated strikingly different phenotypes. A plankton VSP ortholog from
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