Evidence map›Paper›PMID 41303413›Full record

SynthesisInternational journal of molecular sciences2025

Injuries in Artistic Gymnastics: Etiology, Prevention Strategies, and Multifactorial Perspectives-A Systematic Review.

Raid Mekić, Vladan Milić, Oliver Radenković, Ilma Čaprić, Saša Veličković, Rifat Mujanović, Emir Biševac, Elvis Mahmutović, Zerina Salihagić, Aldina Ajdinović and 5 more

Abstract readSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Raid MekićDepartment of Biomedical Sciences, State University of Novi Pazar, 36300 Novi Pazar, Serbia.
Vladan MilićDepartment of Biomedical Sciences, State University of Novi Pazar, 36300 Novi Pazar, Serbia.ORCID 0000-0002-4555-8601
Oliver RadenkovićDepartment of Biomedical Sciences, State University of Novi Pazar, 36300 Novi Pazar, Serbia.ORCID 0000-0001-8165-1590
Ilma ČaprićDepartment of Biomedical Sciences, State University of Novi Pazar, 36300 Novi Pazar, Serbia.ORCID 0000-0002-5266-0727
Saša VeličkovićFaculty of Sport and Physical Education, University of Niš, 18000 Niš, Serbia.ORCID 0000-0002-7670-6451
Rifat MujanovićDepartment of Biomedical Sciences, State University of Novi Pazar, 36300 Novi Pazar, Serbia.ORCID 0000-0002-4628-1798
Emir BiševacDepartment of Biomedical Sciences, State University of Novi Pazar, 36300 Novi Pazar, Serbia.
Elvis MahmutovićDepartment of Biomedical Sciences, State University of Novi Pazar, 36300 Novi Pazar, Serbia.
Zerina SalihagićDepartment of Biomedical Sciences, State University of Novi Pazar, 36300 Novi Pazar, Serbia.ORCID 0000-0002-1909-4727
Aldina AjdinovićDepartment of Biomedical Sciences, State University of Novi Pazar, 36300 Novi Pazar, Serbia.ORCID 0000-0002-7606-8672
Izet KahrovićDepartment of Biomedical Sciences, State University of Novi Pazar, 36300 Novi Pazar, Serbia.
Benin MurićDepartment of Biomedical Sciences, State University of Novi Pazar, 36300 Novi Pazar, Serbia.
Jovan CvejićFaculty of Sport and Physical Education, University of Novi Sad, 21000 Novi Sad, Serbia.
Zoran MojsilovićFaculty of Sport and Physical Education, University of Pristina in Kosovska Mitrovica, 38218 Leposavić, Serbia.ORCID 0000-0001-7430-6342
Igor StanojevićDepartment of Educational Studies Aleksinac, Academy of Educational and Medical Vocational Studies Kruševac, University of Niš, 18220 Aleksinac, Serbia.ORCID 0009-0006-5769-7218

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artistic gymnastics is one of the most physically demanding sports, characterized by a high incidence of both acute and chronic injuries. Although previous research has primarily focused on biomechanical and training-related factors, the multifactorial etiology of injuries-including molecular and genetic aspects-remains insufficiently explored. This systematic review aimed to synthesize current evidence on the causes, mechanisms, and prevention of injuries in artistic gymnastics, with particular emphasis on biomechanical, molecular, and genetic determinants of injury risk and athletic performance. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines and was registered in the PROSPERO database (Registration No: CRD420251167521). Electronic databases (PubMed, KoBSON, and Google Scholar) were searched for studies published between 2015 and 2025 using the keywords "gymnastics injuries," "overuse injuries," "injury prevention," "biomechanics," "IL-6," "TNF-α," and "miRNA biomarkers." Nineteen studies met the inclusion criteria and were analyzed based on injury incidence, localization, mechanisms, and molecular and genetic associations. The majority of injuries were localized in the joints of both upper and lower extremities, particularly during puberty and at higher competitive levels. Repetitive loading, improper technique, and insufficient recovery were identified as the main etiological factors. Molecular biomarkers such as IL-6, TNF-α, and miRNAs (miR-155, miR-146a) were found to play key roles in inflammatory responses, while genetic polymorphisms including ACTN3 R577X, ESR1 rs2234693, and CYP19A1 rs936306 were associated with flexibility, explosive strength, and susceptibility to injury. Injury prevention in artistic gymnastics requires a personalized and multidisciplinary approach that integrates biomechanical, clinical, molecular, and genetic data. Incorporating molecular and genetic profiling into training and rehabilitation programs may enhance early detection of overuse conditions and optimize both health and performance outcomes in gymnasts.

Indexed as

Athletic InjuriesCumulative Trauma DisordersGymnasticsBiomechanical PhenomenaHumansMicroRNAsMicroRNAsbiomechanicsgymnastics injuriesIL-6 and TNF-αinjury preventionmiRNA biomarkersoveruse injuries

Identifiers

PMID41303413
PMCPMC12652705

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.