Evidence map›Paper›PMID 41303412›Full record

ReviewInternational journal of molecular sciences2025

Advances in Artificial Intelligence (AI) Models and Generative Algorithms Represent a New Paradigm for Genomics Research.

Du Hyeong Lee, Eun Gyung Park, Yun Ju Lee, Hyeon-Su Jeong, Hyun-Young Roh, Ga-Ram Jeong, Sang-Woo Kim, Heui-Soo Kim

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Du Hyeong LeeDepartment of Integrated Biological Science, Pusan National University, Busan 46241, Republic of Korea.ORCID 0000-0001-8403-4395
Eun Gyung ParkDepartment of Integrated Biological Science, Pusan National University, Busan 46241, Republic of Korea.ORCID 0000-0002-9575-7043
Yun Ju LeeDepartment of Integrated Biological Science, Pusan National University, Busan 46241, Republic of Korea.ORCID 0000-0002-4578-3323
Hyeon-Su JeongDepartment of Integrated Biological Science, Pusan National University, Busan 46241, Republic of Korea.ORCID 0009-0001-7403-1729
Hyun-Young RohDepartment of Integrated Biological Science, Pusan National University, Busan 46241, Republic of Korea.ORCID 0009-0002-0566-8010
Ga-Ram JeongDepartment of Integrated Biological Science, Pusan National University, Busan 46241, Republic of Korea.ORCID 0009-0001-8415-7608
Sang-Woo KimInstitute of Systems Biology, Pusan National University, Busan 46241, Republic of Korea.
Heui-Soo KimInstitute of Systems Biology, Pusan National University, Busan 46241, Republic of Korea.ORCID 0000-0002-5226-6594

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genomics has developed in step with progress in computing. As computational capabilities have grown, analyses have expanded from simple statistics to artificial intelligence (AI)-based approaches within genomics. The decline in sequencing costs has led to the accumulation of diverse genomic datasets, rapidly accelerating AI for genomic analysis. AI models are now developed and applied across many functional domains, including the prediction of transcription factor binding sites, epigenetic elements, DNA methylation, and noncoding sequence functional annotation. With the maturation of architectures such as deep neural networks, convolutional neural networks, recurrent neural networks, and transformers, many genomic models now accommodate longer inputs, capture long-range context, and integrate complex multi-omics data, thereby steadily improving predictive accuracy. Moreover, the emergence of generative AI has enabled models that can simulate and design genomic sequences. The introduction of generative AI into genomics goes beyond inferring function to the capability of replicating functional genomes. These advances will help advance genome interpretation and accelerate our ability to chart and navigate the genomic landscape.

Indexed as

AlgorithmsArtificial IntelligenceGenomicsComputational BiologyHumansNeural Networks, Computerartificial intelligencebioinformaticsdeep learninggenerative algorithmsgenomicsmachine learning

Identifiers

PMID41303412
PMCPMC12652821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.