Evidence map›Paper›PMID 41303406›Full record

ArticleInternational journal of molecular sciences2025

Retinal Ischemia: Therapeutic Effects and Mechanisms of Paeoniflorin.

Windsor Wen-Jin Chao, Howard Wen-Haur Chao, Pai-Huei Peng, Yi-Tzu Lee, Hsiao-Ming Chao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Windsor Wen-Jin ChaoDepartment of Renal Medicine, New Cross Hospital, Wolverhampton WV10 0QP, UK.
Howard Wen-Haur ChaoDepartment of Renal Medicine, Queen Elizabeth University Hospital, Birmingham B15 2TH, UK.
Pai-Huei PengDepartment of Ophthalmology, Shin Kong Hospital, Taipei 11101, Taiwan.
Yi-Tzu LeeInstitute of Pharmacology, Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.ORCID 0000-0002-6183-4987
Hsiao-Ming ChaoDepartment of Ophthalmology, Shin Kong Hospital, Taipei 11101, Taiwan.ORCID 0000-0002-1545-9936

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinal ischemia is a key factor in the progression of vision-threatening ocular diseases, including central retinal artery/vein occlusion, exudative age-related macular degeneration (eAMD), and proliferative diabetic retinopathy. This study investigates the effects of paeoniflorin along with its related neuroprotective molecular pathways in the treatment of retinal ischemia. Free radical or ischemic-like damage was induced by incubating retinal pigment epithelium (RPE) cells for 24 h with 1 mM hydrogen peroxide (H

Indexed as

GlucosidesIschemiaMonoterpenesRetinal DiseasesAnimalsApoptosisCell SurvivalDisease Models, AnimalGlycosidesHypoxia-Inducible Factor 1, alpha SubunitMaleNeuroprotective AgentsRatsRats, WistarReperfusion InjuryRetinal Pigment EpitheliumGlucosidesGlycosidesHypoxia-Inducible Factor 1, alpha SubunitMonoterpenesNeuroprotective AgentspeoniflorinVascular Endothelial Growth Factor Aangiopoietin-2antioxidationbeta-cateninoxidative stresspaeoniflorinpigment epithelium-derived factorretinal ischemiatraditional Chinese medicineVEGF

Identifiers

PMID41303406
PMCPMC12652814

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.