Evidence map›Paper›PMID 41303402›Full record

ReviewInternational journal of molecular sciences2025

Garcinol as an Epigenetic Modulator: Mechanisms of Anti-Cancer Activity and Therapeutic Potential.

Geethika Pochana, Tejaswini Sai Karanam, Shacoya Mack, Balasubramanyam Karanam

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Geethika PochanaDepartment of Biology and Cancer Research, Tuskegee University, 1200 W Montgomery Rd, Tuskegee, AL 36088, USA.
Tejaswini Sai KaranamDepartment of Biology and Cancer Research, Tuskegee University, 1200 W Montgomery Rd, Tuskegee, AL 36088, USA.
Shacoya MackDepartment of Biology and Cancer Research, Tuskegee University, 1200 W Montgomery Rd, Tuskegee, AL 36088, USA.
Balasubramanyam KaranamDepartment of Biology and Cancer Research, Tuskegee University, 1200 W Montgomery Rd, Tuskegee, AL 36088, USA.ORCID 0000-0002-0782-2539

Funding

Tuskegee University Center for Biomedical Research/ Research Centers at Minority InstitutionsU54MD007585 · NIMHD · TUSKEGEE UNIVERSITY · PI Balasubramanyam Karanam · 2017 to 2026
$29.4M
Carver Genomic Research Center (CGRC)-Building Next Generation Genomic Data Scientist in Rural AlabamaUG3HG013553 · NHGRI · TUSKEGEE UNIVERSITY · PI BEDI, DEEPA · 2024 to 2024
$822k
NHGRI NIH HHS 1UG3HG013553-01NHGRI NIH HHS UG3 HG013553NIMHD NIH HHS 5U54MD007585-34NIMHD NIH HHS U54 MD007585
6 · The paper itself

Abstract

The limitations of conventional cancer therapies, including toxicity and resistance, underscore the need for safer and more versatile alternatives that can either complement or substitute existing regimens. Garcinol, a polyisoprenylated benzophenone derived primarily from the rind and leaves of

Indexed as

Antineoplastic AgentsEpigenesis, GeneticNeoplasmsTerpenesAnimalsGene Expression Regulation, NeoplasticHistone AcetyltransferasesHumansMicroRNAsSignal TransductionAntineoplastic AgentsgarcinolHistone AcetyltransferasesMicroRNAsTerpenesapoptosiscambogincancerGarcinia cambogiaGarcinia indicagarcinolhistone acetyltransferasespolyisoprenylated benzophenone

Identifiers

PMID41303402
PMCPMC12652707

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.