Evidence map›Paper›PMID 41303376›Full record

ReviewInternational journal of molecular sciences2025

Recent Progress of Magnetic Nanomaterials with Enhanced Enzymatic Activities in Antitumor Therapy.

Yifan Zhang, Dongyan Li, Hongxia Liang, Bin Lan, Peidan Chang, Yaoxin Yang, Yuanyuan Cheng, Galong Li, Hongbing Lu

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yifan ZhangCollege of Life Sciences, Northwest University, Xi'an 710069, China.
Dongyan LiCollege of Life Sciences, Northwest University, Xi'an 710069, China.
Hongxia LiangCollege of Life Sciences, Northwest University, Xi'an 710069, China.
Bin LanSchool of Biomedical Engineering, Air Force Medical University, Xi'an 710032, China.
Peidan ChangCollege of Life Sciences, Northwest University, Xi'an 710069, China.
Yaoxin YangSchool of Biomedical Engineering, Air Force Medical University, Xi'an 710032, China.
Yuanyuan ChengSchool of Biomedical Engineering, Air Force Medical University, Xi'an 710032, China.
Galong LiCollege of Life Sciences, Northwest University, Xi'an 710069, China.ORCID 0000-0003-1095-3625
Hongbing LuSchool of Biomedical Engineering, Air Force Medical University, Xi'an 710032, China.ORCID 0000-0003-4181-7239

Funding

Key Research and Development Program of Shaanxi Province 2025SF-YBXM-392National Natural Science Foundation of China 82572373, 82372035
6 · The paper itself

Abstract

Magnetic nanomaterials with enhanced enzymatic activities have garnered significant attention from researchers worldwide. Magnetic nanomaterials, including nanozymes and immobilized enzymes, can initiate specific catalytic reactions in the diseased microenvironment for cancer treatment. In this review, we aim to present the significant advancements in synthesizing various types of magnetic nanomaterials with enhanced enzymatic activities and their antitumor therapy applications in the past five years. We first show the representative magnetic nanomaterials and elucidate their fundamental mechanisms related to magnetic properties and electromagnetic effects (such as magneto-thermal, magneto-mechanical, and magneto-electric effects). Secondly, we introduce magnetic nanozymes and magnetic immobilized enzymes and discuss the creative methods allowing the enzymatic activities of nanomaterials to be remotely enhanced by various electromagnetic effects. We also discuss some innovative magnetic nanomaterials that exhibit unique responsiveness to external energies (such as X-rays and ultrasounds) for killing cancer cells. Finally, we address future research suggestions in rationally designing advanced magnetic nanomaterials with remote increased enzymatic activities and discuss challenges and opportunities for efficient cancer therapy.

Indexed as

Antineoplastic AgentsMagnetite NanoparticlesNanostructuresNeoplasmsAnimalsEnzymes, ImmobilizedHumansAntineoplastic AgentsEnzymes, ImmobilizedMagnetite Nanoparticlesanticancer therapycatalytic activityimmobilized enzymesMNPsnanozymes

Identifiers

PMID41303376
PMCPMC12652109

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.