ReviewInternational journal of molecular sciences2025
Hyaluronan-Based Hybrid Systems as Growth Factor Carriers in the Treatment of Chronic Wounds.
Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Hyaluronic Acid-Based Biomaterials for Soft Tissue Repair and Wound Healing: Clinical Evidence and Emerging Applications.Gels (Basel, Switzerland) · 2026Review
- 3D Bioprinting of Blood Vessel Model for Improving Wound Healing.International journal of molecular sciences · 2026Article
- Hyaluronic Acid-Based Gels and Biomaterial Systems for Oral Wound Healing: Design and Clinical Translation.Gels (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The treatment of wounds, most of which are complications of chronic diseases, poses a significant clinical challenge. Hybrid systems based on hyaluronic acid containing growth factors are a promising prospect for the treatment of chronic wounds. Hyaluronic acid supports fibroblast proliferation, migration, and adhesion to the wound site, and stimulates collagen production. Growth factors (GF), such as epidermal growth factor (EGF), fibroblast growth factor (FGF), and vascular endothelial growth factor (VEGF), influence the normal proliferation and migration of keratinocytes and fibroblasts. This review aims to summarise the current state of knowledge regarding their therapeutic potential. Google Scholar, Web of Science, and Medline (PubMed) databases were searched. Eighteen studies, including basic, preclinical, and clinical studies, were included in the review. The studies confirm the therapeutic potential of the developed formulations. Collagen/hyaluronic acid and alginate/hyaluronic acid systems are biocompatible and biodegradable matrices that provide a moist wound environment, which promotes cell migration and proliferation. EGF stimulates the proliferation and migration of keratinocytes, which accelerates re-epithelialisation. bFGF supports angiogenesis by stimulating the proliferation and migration of vascular endothelial cells. The effect of these actions indirectly leads to increased production of VEGF and HGF cytokines, which support the formation of granulation tissue. The VEGF-containing dressing stimulated vascularisation and the production of collagen type-1 and fibronectin. Only one clinical study conducted in this field indicates the need for further research in this area.
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Registered trials
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