Evidence map›Paper›PMID 41303346›Full record

ArticleInternational journal of molecular sciences2025

IgG Idiotype Diversity Shapes Cytokine Profiles and Autoantibody Targets in HTLV-1 Clinical Outcomes.

Isabela Siuffi Bergamasco, Nicolle Rakanidis Machado, Lais Alves do Nascimento, Beatriz Oliveira Fagundes, Fabio da Ressureição Sgnotto, Jorge Casseb, Sabri Saeed Sanabani, Luiz Henrique Da Silva Nali, Denis Miyashiro, José Antonio Sanches and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Isabela Siuffi BergamascoPost Graduation Program in Health Sciences, Santo Amaro University (UNISA), Sao Paulo 04743-030, Brazil.
Nicolle Rakanidis MachadoLaboratory of Medical Investigation LIM-56, Division of Dermatology, Medical School, University of Sao Paulo, Sao Paulo 05403-000, Brazil.ORCID 0000-0002-8605-9104
Lais Alves do NascimentoLaboratory of Medical Investigation LIM-56, Division of Dermatology, Medical School, University of Sao Paulo, Sao Paulo 05403-000, Brazil.
Beatriz Oliveira FagundesLaboratory of Medical Investigation LIM-56, Division of Dermatology, Medical School, University of Sao Paulo, Sao Paulo 05403-000, Brazil.
Fabio da Ressureição SgnottoPost Graduation Program in Health Sciences, Santo Amaro University (UNISA), Sao Paulo 04743-030, Brazil.
Jorge CassebLaboratory of Medical Investigation LIM-56, Division of Dermatology, Medical School, University of Sao Paulo, Sao Paulo 05403-000, Brazil.ORCID 0000-0002-4553-2559
Sabri Saeed SanabaniLaboratory of Medical Investigation LIM-03, Clinics Hospital, Medical School, University of Sao Paulo, Sao Paulo 05403-010, Brazil.ORCID 0000-0002-8876-8262
Luiz Henrique Da Silva NaliPost Graduation Program in Health Sciences, Santo Amaro University (UNISA), Sao Paulo 04743-030, Brazil.ORCID 0000-0002-8365-9796
Denis MiyashiroDivision of Dermatology, Medical School, University of Sao Paulo, Sao Paulo 05403-010, Brazil.ORCID 0000-0002-1959-4908
José Antonio SanchesDivision of Dermatology, Medical School, University of Sao Paulo, Sao Paulo 05403-010, Brazil.ORCID 0000-0002-5709-092X
Jefferson Russo VictorPost Graduation Program in Health Sciences, Santo Amaro University (UNISA), Sao Paulo 04743-030, Brazil.ORCID 0000-0001-6092-8394

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/08225-8National Council for Scientific and Technological Development 302937/2021-8 and 402406/2024-9the Laboratory of Medical Investigation-56, Medical School, University of São Paulo LIM-56 HC-FMUSP
6 · The paper itself

Abstract

Human T-lymphotropic virus type 1 (HTLV-1) infection is associated with a spectrum of clinical outcomes, ranging from lifelong asymptomatic carriage to severe conditions such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukemia/lymphoma (ATLL). Although antibody responses are known to shape immune regulation, the functional relevance of IgG idiotype repertoires in HTLV-1 pathogenesis remains poorly understood. This study investigated the immunomodulatory effects of IgG from individuals with distinct HTLV-1 clinical outcomes. IgG was purified from pooled serum samples of asymptomatic carriers (ACs), HAM/TSP, and ATLL patients and used to stimulate peripheral blood mononuclear cells (PBMCs) from healthy donors. Cytokine production in CD4

Indexed as

AutoantibodiesCytokinesHTLV-I InfectionsHuman T-lymphotropic virus 1Immunoglobulin GLeukemia-Lymphoma, Adult T-CellAdultAgedCD4-Positive T-LymphocytesFemaleHumansMaleMiddle AgedParaparesis, Tropical SpasticAutoantibodiesCytokinesImmunoglobulin GATLLautoantibodiesHAM/TSPHTLV-1IgG

Identifiers

PMID41303346
PMCPMC12652327

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.