Evidence map›Paper›PMID 41303324›Full record

ArticleInternational journal of molecular sciences2025

MicroRNA-210 Suppresses NF-κB Signaling in Lipopolysaccharide-Stimulated Dental Pulp Cells Under Hypoxic Conditions.

Xiyuan Bai, Nobuyuki Kawashima, Shihan Wang, Peifeng Han, Mayuko Fujii, Keisuke Sunada-Nara, Ziniu Yu, Takashi Okiji, Yoshio Yahata

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiyuan BaiDepartment of Pulp Biology and Endodontics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8549, Japan.ORCID 0009-0004-8152-4195
Nobuyuki KawashimaDepartment of Pulp Biology and Endodontics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8549, Japan.ORCID 0000-0002-1636-0487
Shihan WangDepartment of Pulp Biology and Endodontics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8549, Japan.ORCID 0009-0000-9926-9533
Peifeng HanDepartment of Pulp Biology and Endodontics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8549, Japan.ORCID 0000-0002-1442-9102
Mayuko FujiiDepartment of Pulp Biology and Endodontics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8549, Japan.
Keisuke Sunada-NaraDepartment of Pulp Biology and Endodontics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8549, Japan.
Ziniu YuDepartment of Pulp Biology and Endodontics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8549, Japan.ORCID 0009-0005-0533-5664
Takashi OkijiDepartment of Pulp Biology and Endodontics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8549, Japan.ORCID 0000-0002-9791-4508
Yoshio YahataDepartment of Pulp Biology and Endodontics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8549, Japan.

Funding

Japan Society for the Promotion of Science 22K09960ZAJapan Society for the Promotion of Science 24K12909ZAJapan Society for the Promotion of Science 24K19891ZA
6 · The paper itself

Abstract

Dental pulp tissue, enclosed within rigid dentin, is susceptible to bacterial invasion via dentinal tubules, often leading to severe pulpal inflammation. This condition is typically associated with a hypoxic microenvironment, yet the mechanistic link between hypoxia and inflammation remains unclear. We identified a marked upregulation of microRNA-210 (miR-210) in human dental pulp cells (hDPCs) cultured under hypoxic conditions. This study investigated the role of miR-210 in modulating inflammation in lipopolysaccharide (LPS)-stimulated hDPCs. Hypoxic conditions and enforced expression of hypoxia-inducible factor 1α (HIF1α) significantly increased miR-210 levels. While LPS stimulation elevated proinflammatory cytokines (

Indexed as

Dental PulpLipopolysaccharidesMicroRNAsNF-kappa BSignal TransductionAdaptor Proteins, Signal TransducingAnimalsCell HypoxiaCells, CulturedCytokinesHumansHypoxia-Inducible Factor 1, alpha SubunitRatsAdaptor Proteins, Signal TransducingCytokinesHypoxia-Inducible Factor 1, alpha SubunitLipopolysaccharidesMicroRNAsMIRN210 microRNA, humanNF-kappa Bhuman dental pulp cellhypoxic conditionsmicroRNA-210NF-κB signaling pathwayproinflammatory cytokineTGF-beta activated kinase 1 binding protein 1

Identifiers

PMID41303324
PMCPMC12652713

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.