ReviewInternational journal of molecular sciences2025
Hydrogel Design Based on Bacterial Exopolysaccharides: The Biomedical Promise of Levan.
Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Research Progress on Natural Polysaccharide Hydrogels in the Diagnosis and Treatment of Colorectal Cancer.Gels (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial exopolysaccharides have emerged as versatile biopolymers for the design of advanced hydrogels with adjustable physico-chemical, mechanical, and biological properties. Among these, levan, a fructose-based exopolysaccharide synthesized by various microbial species, has attracted increasing attention due to its unique structural features, high biocompatibility, and inherent bioactivity. This review provides a comprehensive overview of hydrogel systems derived from bacterial exopolysaccharides, with a particular focus on levan-based hydrogels. We discuss the molecular structure, synthesis pathways, and physico-chemical characteristics of levan that underpin its hydrogel-forming ability. Emphasis is placed on design strategies, including chemical modification, crosslinking approaches, and composite formation, that enable fine-tuning of mechanical strength, swelling behavior, and degradation kinetics. This review further highlights biomedical applications of levan-based hydrogels, encompassing drug delivery, wound healing, rejuvenation, tissue engineering, regenerative medicine, and bioprinting, while addressing current limitations and future research directions. By elucidating the structure-function relationships and emerging fabrication methodologies, this review underscores the biomedical promise of levan as a sustainable and functional biopolymer for next-generation hydrogel technologies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.