Evidence map›Paper›PMID 41303198›Full record

ReviewJournal of clinical medicine2025

Implantation Failure: Where to Look Up?

Antonis Makrigiannakis, Tatjana Motrenko, Marwa Lahimer, Fanourios Ioannis Makrygiannakis, Rosalie Cabry, Jan Tesarik, Moncef Benkhalifa

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Antonis MakrigiannakisDepartment of Obstetrics and Gynecology, University Hospital and School of Medicine, University of Crete, 71003 Heraklion, Greece.
Tatjana MotrenkoHuman Reproduction Center, 85310 Budva, Montenegro.
Marwa LahimerIVF & Reproductive Genetics, University Hospital and School of Medicine, Picardie University Jules Verne, Centre Hospital-Universitaire Amiens Sud, 80000 Amiens, France.ORCID 0009-0002-9685-7633
Fanourios Ioannis MakrygiannakisDepartment of Obstetrics and Gynecology, University Hospital and School of Medicine, University of Crete, 71003 Heraklion, Greece.ORCID 0000-0002-2413-9176
Rosalie CabryIVF & Reproductive Genetics, University Hospital and School of Medicine, Picardie University Jules Verne, Centre Hospital-Universitaire Amiens Sud, 80000 Amiens, France.
Jan TesarikMARGen Clinic, 18002 Granada, Spain.ORCID 0000-0003-4645-5804
Moncef BenkhalifaIVF & Reproductive Genetics, University Hospital and School of Medicine, Picardie University Jules Verne, Centre Hospital-Universitaire Amiens Sud, 80000 Amiens, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A competent embryo and a receptive endometrium are essential for adequate embryo-maternal cross-talk and successful implantation. However, the majority of women undergoing IVF do not achieve pregnancy after the first embryo transfer, incriminating potential implantation issues. According to statistics, recurrent implantation failure (RIF), for which different definitions have been proposed, is estimated to affect about 10-25% of women undergoing in vitro fertilization (IVF). RIF is a complex condition with overlapping causes. The primary objective of this review is to explore factors such as gamete and embryo quality, chromosomal abnormalities, uterine environment, endometrial receptivity, immune cell biomarkers, and microbiota dysregulation to better understand and overcome RIF challenges. It also highlights the significance of comprehensive evaluations of novel therapies, such as activated autologous platelet-rich plasma (PRP) or peripheral blood mononuclear cell (PBMC) insemination, on pregnancy outcomes in patients with RIF.

Indexed as

endometrial receptivityeuploid embryo transferlifestyle factorsrecurrent implantation failureuterine cavity

Identifiers

PMID41303198
PMCPMC12653490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.