ReviewJournal of clinical medicine2025
Microbial Biofilms as Barriers to Chronic Wound Healing: Diagnostic Challenges and Therapeutic Advances.
Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- An update on biofilms in acute and chronic wounds: Incidence, clinical evidence, diagnosis, prevention, and treatment.Journal of internal medicine · 2026Review
- An integrative review of wound healing: anatomy, molecular mediators, and indigenous therapies.Molecular biology reports · 2026Review
- Graphene Oxide and Methylglyoxal: a combined strategy against chronic wound pathogens.Applied microbiology and biotechnology · 2026Article
- Plant-Mediated Silver Nanoparticle Formulations for Wound Healing: A Process-Property-Performance Perspective.Pharmaceutics · 2026Review
- Highly Efficient Photodynamic Inactivation of Multidrug-resistant Pseudomonas aeruginosa, Staphylococcus aureus and Acinetobacter baumannii Strains by Toluidine Blue-graphene Oxide Quantum Dot/Ag Nanoparticle Conjugate.Current microbiology · 2026Article
- Cold Atmospheric Plasma Disrupts Microbial Wound Bioburden: In Vitro, Porcine MRSA Biofilm, and Clinical Fluorescence Evidence from Bench to Bedside.Biomedicines · 2026Article
- Clinical Outcomes of an Individualized Multimodal Chronic Wound Management Protocol Using Type I Collagen-Hyaluronic Acid Pads: Retrospective Observational Study.Journal of personalized medicine · 2026Article
- Targeting Biofilms in Chronic Wounds: Emerging Strategies with Antimicrobial Nanocomposites.Journal of functional biomaterials · 2026Review
- Multifunctional Silk Fibroin Hydrogel with Antibacterial and Regenerative Properties for Accelerated Wound Healing.Gels (Basel, Switzerland) · 2026Article
- Low-frequency ultrasound-assisted application of Ag/Cu nanocomposites as a promising strategy for the treatment of purulent wounds.Discover nano · 2026Article
- Burn Infections and Sepsis: Challenges and Future Prospects of Antibacterial Therapy.Antibiotics (Basel, Switzerland) · 2026Review
- Polysaccharide based biomaterials for advanced wound healing applications.Frontiers in cellular and infection microbiology · 2026Review
- Antimicrobial Strategies for Chronic Cutaneous Ulcers: From Preclinical Nanotechnology to Clinical Practice.International journal of nanomedicine · 2026Review
- Biofilm-Responsive Nanoplatforms for Infected Wound Reconstruction.International journal of nanomedicine · 2026Review
- Surfactant-Engineered Niosomal Antibiotic Systems for Biofilm-Associated Infections: Design Principles and Translational Perspectives.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wound healing is a complex and multistage process that incorporates precise cellular and molecular coordination. The presence of biofilms in chronic wounds adversely affects the wound healing process, as it prolongs the closure of the wound, thus sustaining chronic inflammation. Current data suggest that biofilms are present in almost all chronic wounds, which leads to significant challenges in diagnosis and treatment. Traditional detection methods, such as cultures and light microscopy, often fail to detect biofilms; however, sophisticated molecular and imaging techniques are constrained by their expense and accessibility. Chronic wound management, therefore, has progressed from conventional antimicrobial application to integrated methodologies that incorporate biofilm debridement, antibiofilm dressing, negative pressure wound therapy, and innovative enzyme or nanoparticle interventions. This review highlights the clinical significance of biofilm presence as a barrier in chronic wound healing, assesses diagnostic and therapeutic innovations, and stresses the urgent need to improve patient outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.