Evidence map›Paper›PMID 41303070›Full record

ArticleJournal of clinical medicine2025

Breastfeeding in a Polluted World: Perspective on the Properties of Breast Milk and the Need for Protection.

Maria Elisabeth Street, Anna-Mariia Shulhai, Vassilios Fanos, Anna Maria Papini, Davide Ponzi, Antonio Ragusa, Dolores Rollo, Paola Palanza

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria Elisabeth StreetDepartment of Medicine and Surgery, University of Parma, 43121 Parma, Italy.ORCID 0000-0001-8427-8971
Anna-Mariia ShulhaiDepartment of Medicine and Surgery, University of Parma, 43121 Parma, Italy.ORCID 0000-0002-7849-4560
Vassilios FanosSection of Neonatal Intensive Care Unit, Department of Paediatrics, Puericulture Institute and Neonatal Section, Azienda Mista, University of Cagliari, 09124 Cagliari, Italy.
Anna Maria PapiniInterdepartmental Research Unit of Peptide and Protein Chemistry and Biology (Peptlab), Centre of Competences in Molecular Diagnostics and Life Sciences (MoD&LS), University of Florence, 50121 Sesto Fiorentino, Italy.ORCID 0000-0002-2947-7107
Davide PonziDepartment of Medicine and Surgery, University of Parma, 43121 Parma, Italy.ORCID 0000-0001-5112-8336
Antonio RagusaDepartment of Obstetrics and Gynecology, Hospital of Sassuolo, 41049 Modena, Italy.ORCID 0000-0002-2579-1027
Dolores RolloDepartment of Medicine and Surgery, University of Parma, 43121 Parma, Italy.
Paola PalanzaDepartment of Medicine and Surgery, University of Parma, 43121 Parma, Italy.ORCID 0000-0003-2873-4260

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast milk (BM) is a unique biological fluid that represents the optimal nutritional source for infants, uniquely adapted through millions of years of evolution. BM is not only a nutritional fluid but a dynamic biological system, evolved to provide optimal growth, immune protection, and neurodevelopmental support. Its unique composition-including macronutrients, micronutrients, bioactive molecules, and stem cells-makes it essential in early life. Breastfeeding further promotes psychological well-being, secure attachment, and maternal-infant bonding. Yet, in recent decades, concern has grown over environmental contaminants in BM, including endocrine-disrupting chemicals (EDCs) and micro/nanoplastics. These pollutants have the potential to disrupt endocrine signaling, neurodevelopment, metabolic programming, and immune development, thereby undermining the natural advantages of breastfeeding. Therefore, a better understanding of the unique features of BM, while investigating the effects of these contaminants, is important for safeguarding maternal and infant health. This perspective article highlights the current knowledge on BM and indicates the need for further research. It also emphasizes the need for appropriate public health measures aimed at reducing exposure to pollutants and lowering associated risks, as well as preventive strategies to protect breast milk and breastfeeding in such a changing environment, as it is uniquely designed to promote the health of children.

Indexed as

analytical chemistrybiomonitoringbreast milkendocrine-disrupting chemicalsenvironmental exposurehuman healthhuman milkmicroplasticsnanoplasticstoxicology

Identifiers

PMID41303070
PMCPMC12653506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.