Evidence map›Paper›PMID 41302619›Full record

ArticleInternational journal of environmental research and public health2025

Instability in the Penta-C and Penta-D Loci in Microsatellite-Unstable Endometrial Cancer.

Ahmet Yilmaz, Wendy L Frankel, Weiqiang Zhao, Adrian A Suarez, Wei Chen, Joshua F Coleman, Joseph P McElroy, Rachel Pearlman, Paul J Goodfellow, Heather Hampel

Abstract read
In one paragraph

Article in International journal of environmental research and public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ahmet YilmazDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Wendy L FrankelDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Weiqiang ZhaoDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Adrian A SuarezDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Wei ChenDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.ORCID 0000-0002-9028-622X
Joshua F ColemanDepartment of Pathology, University of Utah, Salt Lake City, UT 84112, USA.
Joseph P McElroyCenter for Biostatistics, Department of Biomedical Informatics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.
Rachel PearlmanDepartment of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Paul J GoodfellowDepartment of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Heather HampelDivision of Clinical Cancer Genomics, Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.ORCID 0000-0001-7558-9794

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometrial cancer (EC) is the most common gynecologic cancer. Early detection is one of the most important predictors of survival. The cancer is curable if detected early but the five-year survival rate in advanced cases can be as low as 22%. Microsatellite instability (MSI) testing is used to screen populations for Lynch Syndrome (LS), the most common cause of inherited EC, and to classify EC into distinct groups with unique histological, prognostic, and molecular features. Accurate sample identification is crucial for successful MSI testing because instability is assessed by comparing amplification patterns in markers in the normal and tumor samples that must be taken from the same individual. Penta-C and Penta-D pentanucleotide markers are used widely for sample identification in not only MSI testing but also parentage verification, forensic science, and population genetics studies. The objective of this study was to test 324 pairs of tumor and matched normal DNAs from EC patients for instability in these markers using the Promega MSI Analysis System

Indexed as

Endometrial NeoplasmsMicrosatellite InstabilityMicrosatellite RepeatsFemaleHumansMiddle AgedDNA mismatch repairendometrial cancerimmunohistochemistrymicrosatellite instabilityPenta-CPenta-D

Identifiers

PMID41302619
PMCPMC12652968

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.