ArticleMolecules (Basel, Switzerland)2025
Effective Antioxidants as Plausible Ligands in Chromium(III) Supplementation: How Complexation Modulates Catechol-Based Polyphenols.
Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Chromium(III) Beyond Insulin: A Mechanistic Roadmap Across the Energy-Redox-Inflammation Triad in Obesity and Cardiometabolic Disease.Biological trace element research · 2026Review
- Microalgae-based integrated treatment of tannery wastewater: emphasizing microbial synergy for sustainable remediation.RSC advances · 2026Review
- Towards the Development of Effective Antioxidants-The Molecular Structure and Properties-Part 2.Molecules (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
This study examines the impact of metal coordination on the antioxidant and pro-oxidant properties of 3,4-dihydroxybenzoic acid (3,4-DHBA) and caffeic acid (CA). Their Na(I), K(I) salts and Cr(III) complexes were evaluated in vitro using radical scavenging assays (ABTS, DPPH, hydroxyl, and superoxide), ferric- and cupric-reducing power, and inhibition of linoleic acid peroxidation. Alkali metal coordination generally decreased radical scavenging activity, though K complexes and Cr-3,4-DHBA improved lipid peroxidation inhibition. Cr(III) chelation produced ligand-dependent effects: it markedly increased the reducing power of CA while reducing that of 3,4-DHBA and uniquely promoted pro-oxidant behavior in CA under superoxide conditions. These outcomes reflect how chromium chelation alters electronic distribution and charge transfer, enhancing reducing power in single-electron transfer assays while enabling redox cycling in radical scavenging systems, underscoring its dual and ligand-dependent biological significance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.