Synthesis of 1,2,4-Triazole-3-Thiol Derivatives from Thiosemicarbazides and Carboxylic Acids Using Polyphosphate Ester.

Bogdan A Tretyakov, Viktoria I Tikhonova, Svyatoslav Y Gadomsky, Nataliya A Sanina

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Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Bogdan A TretyakovFederal Research Center of Problems of Chemical Physics and Medicinal Chemistry RAS, Chernogolovka 142432, Russia.ORCID 0000-0002-4819-6124

Viktoria I TikhonovaFederal Research Center of Problems of Chemical Physics and Medicinal Chemistry RAS, Chernogolovka 142432, Russia.

Svyatoslav Y GadomskyFederal Research Center of Problems of Chemical Physics and Medicinal Chemistry RAS, Chernogolovka 142432, Russia.ORCID 0000-0001-5481-7305

Nataliya A SaninaFederal Research Center of Problems of Chemical Physics and Medicinal Chemistry RAS, Chernogolovka 142432, Russia.ORCID 0000-0002-5344-6220

Funding

Russian Science Foundation 25-73-20036

6 · The paper itself

Abstract

Conditions have been established for the direct reaction of thiosemicarbazides with carboxylic acids in the presence of polyphosphate ester (PPE) to synthesize 1,2,4-triazole-3-thiol derivatives. The synthesis involves two consecutive steps: (i) acylation of the thiosemicarbazide with a carboxylic acid in chloroform in the presence of PPE at 90 °C using a hydrothermal reaction vessel, followed by (ii) cyclodehydration of the acylation product by treatment with an aqueous alkali solution. Using this new synthetic approach, 15 derivatives of 1,2,4-triazole-3-thiol were obtained, five of which were synthesized for the first time. The structures of the synthesized compounds were confirmed by NMR spectroscopy and mass spectrometry.

Indexed as

1,2,4-triazole-3-thiolsacylationcyclodehydrationhydrothermal reactorpolyphosphate esterthiosemicarbazidetriazoles

Identifiers

PMID41302479

DOI10.3390/molecules30224422

PMCPMC12655543

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