Evidence map›Paper›PMID 41302475›Full record

ArticleMolecules (Basel, Switzerland)2025

Polyphenols as Potential β-Lactamase Inhibitors: An Integrated Computational and Experimental Study.

Fatima Mourabiti, Fatimazahra Jouga, Lorena G Calvo, Rosa-Antía Villarino, Yassine Zouheir, Abdelaziz Soukri, Trinidad de Miguel, Bouchra El Khalfi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fatima MourabitiLaboratory of Health, Environment and Biotechnology, Team of Physiopathology, Molecular Genetics and Biotechnology, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Casablanca 20100, Morocco.ORCID 0009-0007-9259-5759
Fatimazahra JougaLaboratory of Health, Environment and Biotechnology, Team of Physiopathology, Molecular Genetics and Biotechnology, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Casablanca 20100, Morocco.
Lorena G CalvoDepartment of Microbiology and Parasitology, Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain.ORCID 0000-0001-5965-5077
Rosa-Antía VillarinoDepartment of Microbiology and Parasitology, Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain.ORCID 0000-0003-1529-7217
Yassine ZouheirLaboratory of Molecular Bacteriology, Pasteur Institute, Casablanca 20250, Morocco.
Abdelaziz SoukriLaboratory of Health, Environment and Biotechnology, Team of Physiopathology, Molecular Genetics and Biotechnology, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Casablanca 20100, Morocco.
Trinidad de MiguelDepartment of Microbiology and Parasitology, Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain.ORCID 0000-0002-0389-6610
Bouchra El KhalfiLaboratory of Health, Environment and Biotechnology, Team of Physiopathology, Molecular Genetics and Biotechnology, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Casablanca 20100, Morocco.ORCID 0000-0002-1318-6233

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The production of β-lactamases is the main mechanism underlying carbapenem resistance. This study combined in silico and in vitro approaches to identify potential polyphenols as carbapenemase inhibitors. Molecular docking, molecular dynamics, and ADMET prediction were performed to assess the binding affinity, stability, and safety of quercetin, kaempferol, caffeic acid, and 3,4-dihydroxybenzoic acid against KPC-2, NDM-1, and OXA-48 carbapenemases. In vitro antibacterial assays and checkerboard analyses were conducted against

Indexed as

Bacterial Proteinsbeta-Lactamase Inhibitorsbeta-Lactamasesbeta-Lactam ResistancePolyphenolsCaffeic AcidsEscherichia coliKaempferolsKlebsiella pneumoniaeMicrobial Sensitivity TestsMolecular Docking SimulationPseudomonas aeruginosaQuercetinBacterial Proteinsbeta-Lactamase Inhibitorsbeta-Lactamasescaffeic acidCaffeic AcidscarbapenemasekaempferolKaempferolsPolyphenolsQuercetinantibiotic potentiationcarbapenemasesGram-negative bacteriain silicomolecular dockingβ-lactamases inhibition

Identifiers

PMID41302475
PMCPMC12655399

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.