Evidence map›Paper›PMID 41302411›Full record

ArticleMolecules (Basel, Switzerland)2025

Synthesis, Antibacterial Properties and Molecular Docking Studies of Nitrogen Substituted 9-(((4X-But-2-ynyloxy)methyl)-1,2,3-triazolyl)-Cinchona Alkaloid Conjugates.

Gulim K Mukusheva, Nurizat N Toigambekova, Victor A Savelyev, Andrey I Khlebnikov, Liubov G Burova, Sofiia D Afanaseva, Oralgazy A Nurkenov, Anarkul S Kishkentayeva, Aikerim S Olzhabayeva, Yurii V Gatilov and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Gulim K MukushevaChemistry Faculty, Karaganda National Research University Buketov, Karaganda 100024, Kazakhstan.
Nurizat N ToigambekovaChemistry Faculty, Karaganda National Research University Buketov, Karaganda 100024, Kazakhstan.
Victor A SavelyevVorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Andrey I KhlebnikovKizhner Research Center, Tomsk Polytechnic University, Tomsk 634050, Russia.ORCID 0000-0002-3022-4510
Liubov G BurovaDepartment of Microbiology, Immunology and Virology, Novosibirsk State Medical University, Krasny Prospect 52, Novosibirsk 630091, Russia.
Sofiia D AfanasevaDepartment of Microbiology, Immunology and Virology, Novosibirsk State Medical University, Krasny Prospect 52, Novosibirsk 630091, Russia.ORCID 0009-0003-6963-4503
Oralgazy A NurkenovInstitute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda 100008, Kazakhstan.ORCID 0000-0003-1878-2787
Anarkul S KishkentayevaSchool of Pharmacy, Karaganda Medical University, Karaganda 100012, Kazakhstan.ORCID 0000-0002-9169-3492
Aikerim S OlzhabayevaChemistry Faculty, Karaganda National Research University Buketov, Karaganda 100024, Kazakhstan.
Yurii V GatilovVorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.ORCID 0000-0002-4128-7293
Roza B SeidakhmetovaDepartment of Clinical Pharmacology and Evidence-Based Medicine, Karaganda Medical University, Karaganda 100012, Kazakhstan.
Alexander N EvstropovDepartment of Microbiology, Immunology and Virology, Novosibirsk State Medical University, Krasny Prospect 52, Novosibirsk 630091, Russia.
Elvira E ShultsVorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.ORCID 0000-0002-0761-9696

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The year 2024 marked the 80th anniversary of Woodward's total synthesis of quinine. Quinine is a natural alkaloid from the bark of the cinchona tree that has been used for years as an antimalarial drug. The antibacterial effect of quinine salts has also been regarded. With this in mind, a series of original 9-deoxycinchone alkaloid derivatives bearing a dialkylamino- or heterocyclic moiety at the 4 position of the 9-(((4-X-but-2-ynyloxy)methyl)-1,2,3-triazolyl)-substituent was synthesized. The copper-catalyzed three-component A

Indexed as

Anti-Bacterial AgentsCinchona AlkaloidsMolecular Docking SimulationNitrogenMicrobial Sensitivity TestsMolecular StructureStaphylococcus aureusStructure-Activity RelationshipAnti-Bacterial AgentsCinchona AlkaloidsNitrogenA3-coupling reactionsantibacterial activitybacterial biofilmscinchona alkaloidsmolecular docking studyquininetriazoles

Identifiers

PMID41302411
PMCPMC12654649

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.