Evidence map›Paper›PMID 41302090›Full record

ArticleLife (Basel, Switzerland)2025

White Matter Integrity of the Corpus Callosum Mediates the Association Between Aging and Skin Condition.

Daihaoyi Yuan, Keisuke Kokubun, Kiyotaka Nemoto, Yoshinori Yamakawa

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Daihaoyi YuanGraduate School of Economics, Kyoto University, Kyoto 606-8501, Japan.
Keisuke KokubunOpen Innovation Institute, Kyoto University, Kyoto 606-8501, Japan.ORCID 0000-0002-7440-5049
Kiyotaka NemotoDepartment of Medical Informatics and Management and Psychiatry, Institute of Medicine, University of Tsukuba, Tsukuba 305-8577, Japan.ORCID 0000-0001-8623-9829
Yoshinori YamakawaOpen Innovation Institute, Kyoto University, Kyoto 606-8501, Japan.ORCID 0000-0002-7995-1794

Funding

ImPACT Program of the Council for Science, Technology and Innovation (Cabinet Office, Government of Japan) nillJSPS KAKENHI JP17H06151JSPS KAKENHI JP25K15384
6 · The paper itself

Abstract

This study examines whether white matter integrity mediates the link between psychological stress and skin aging. This cross-sectional study included 92 healthy Japanese adults (aged 22-62 years) who underwent diffusion tensor imaging to obtain Fractional Anisotropy Brain Healthcare Quotients (FA-BHQs) for major white matter tracts, while skin aging was assessed using Motion Scan Technology. Correlation analyses revealed significant associations among stress, skin aging, and FA-BHQ in the corpus callosum (CC) and internal capsule (IC). Mediation analyses suggested, at the statistical level, a potential that the CC fully mediates the association between stress and skin aging. These findings suggest a relationship between interhemispheric white matter integrity, psychological stress, and skin aging in line with the concept of the brain-skin axis.

Indexed as

diffusion tensor imagingskin agingwhite matter fractional anisotropywhite matter integrity

Identifiers

PMID41302090
PMCPMC12653096

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.