Evolutionary Dynamics of Matrix Metalloproteases with Collagenolytic Activity in Teleosts.

Rafael Angelakopoulos, Andreas Tsipourlianos, Ioannis Damianos Maravelakis, Themistoklis Giannoulis, Zissis Mamuris, Katerina A Moutou

Abstract read

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In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rafael AngelakopoulosLaboratory of Genetics, Comparative and Evolutionary Biology, Department of Biochemistry and Biotechnology, University of Thessaly, 41500 Larissa, Greece.ORCID 0000-0002-2354-2019

Andreas TsipourlianosLaboratory of Genetics, Comparative and Evolutionary Biology, Department of Biochemistry and Biotechnology, University of Thessaly, 41500 Larissa, Greece.ORCID 0009-0000-4964-557X

Ioannis Damianos MaravelakisLaboratory of Genetics, Comparative and Evolutionary Biology, Department of Biochemistry and Biotechnology, University of Thessaly, 41500 Larissa, Greece.

Themistoklis GiannoulisLaboratory of Biology, Genetics and Bioinformatics, Department of Animal Science, University of Thessaly, 41334 Larissa, Greece.ORCID 0000-0002-1842-5432

Zissis MamurisLaboratory of Genetics, Comparative and Evolutionary Biology, Department of Biochemistry and Biotechnology, University of Thessaly, 41500 Larissa, Greece.ORCID 0000-0002-6868-8927

Katerina A MoutouLaboratory of Genetics, Comparative and Evolutionary Biology, Department of Biochemistry and Biotechnology, University of Thessaly, 41500 Larissa, Greece.ORCID 0000-0002-6429-3776

Funding

This work funded by the European Union through project H2020-SFS2016-2-727610 "PerformFISH: Consumer-driven production: Integrating Innovative Approaches for Competitive and Sustain-able Performance across the Mediterranean Aquaculture Value Chain". H2020-SFS2016-2-727610

6 · The paper itself

Abstract

Matrix metalloproteases (MMPs) are zinc-dependent endopeptidases that are critical for extracellular matrix (ECM) remodeling, with key roles in tissue development and repair, and immune responses. Despite their evolutionary and functional importance, the diversification and regulatory dynamics of MMPs genes in teleosts remain poorly understood. This study investigates the evolutionary history of MMPs with collagenolytic activity in the vertebrates with an emphasis on teleosts. Using comparative genomics and phylogenetics we identified conserved single-copy

Indexed as

matrix metalloproteases (MMPs)regulatory sub-functionalizationteleost evolutionwhole-genome duplication

Identifiers

PMID41301977

DOI10.3390/ani15223270

PMCPMC12649390

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.