Evidence map›Paper›PMID 41301947›Full record

ArticleAnimals : an open access journal from MDPI2025

Bioavailability of Thymol Incorporated into Gastro-Resistant Self-Emulsifying Pellets in Rabbits.

Radoslava Kristofova, Karin Zitterl-Eglseer, Fardad Firooznia, Andrea Laukova, Lubica Chrastinova, Monika Pogany Simonova, Margareta Takacsova, Kristina Bacova, Iveta Placha

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Radoslava KristofovaDepartment of Digestive Tract Physiology, Institute of Animal Physiology, Centre of Biosciences, Slovak Academy of Sciences, Soltesovej 4-6, 040 01 Kosice, Slovakia.ORCID 0000-0002-5169-2858
Karin Zitterl-EglseerCentre for Veterinary Systems Transformation and Sustainability, Clinical Department for Farm Animal and Food Systems Science, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, Austria.ORCID 0000-0002-6908-7074
Fardad FiroozniaDepartment of Biology, The City College of New York, 160 Convent Avenue, New York, NY 10031, USA.
Andrea LaukovaDepartment of Digestive Tract Physiology, Institute of Animal Physiology, Centre of Biosciences, Slovak Academy of Sciences, Soltesovej 4-6, 040 01 Kosice, Slovakia.ORCID 0000-0001-7413-3816
Lubica ChrastinovaAnimal Production Research Centre, National Agricultural and Food Centre, Hlohovecka 2, 951 41 Nitra-Luzianky, Slovakia.
Monika Pogany SimonovaDepartment of Digestive Tract Physiology, Institute of Animal Physiology, Centre of Biosciences, Slovak Academy of Sciences, Soltesovej 4-6, 040 01 Kosice, Slovakia.ORCID 0000-0002-0377-4672
Margareta TakacsovaDepartment of Digestive Tract Physiology, Institute of Animal Physiology, Centre of Biosciences, Slovak Academy of Sciences, Soltesovej 4-6, 040 01 Kosice, Slovakia.ORCID 0000-0002-7478-9177
Kristina BacovaDepartment of Digestive Tract Physiology, Institute of Animal Physiology, Centre of Biosciences, Slovak Academy of Sciences, Soltesovej 4-6, 040 01 Kosice, Slovakia.ORCID 0000-0002-1856-4475
Iveta PlachaDepartment of Digestive Tract Physiology, Institute of Animal Physiology, Centre of Biosciences, Slovak Academy of Sciences, Soltesovej 4-6, 040 01 Kosice, Slovakia.ORCID 0000-0002-8724-0159

Funding

CNR-SAS (Italy-Slovakia) 2022-02COST CA22109OeAD, Austria´s Agency for Education and Internationalisation, Ernst-Mach Grant Action Austria-Slovakia MPC-2023-01046Open-Mob (Austria-Slovakia) 2022-01Scientific Grant Agency of the Ministry for Education, Science, Research and Sport of the Slovak Republic and the Slovak Academy of Sciences 2/0005/24
6 · The paper itself

Abstract

Thymol gastro-resistant self-emulsifying pellets were used to achieve thymol targeted release on the side of the intestine with the most intensive absorption to enhance its oral bioavailability. Forty-eight rabbits (35 d of age) were divided into two groups fed with a standard diet containing gastro-resistant enteric pellets (control, CG; without thymol, initial live weight 1350.0 ± 18.0, and experimental, EG; with thymol 250 mg/kg, initial live weight 1352.0 ± 19.9 g). The experiment lasted 28 days: thymol was administered for 21 days and then withdrawn for 7 days. Thymol was significantly higher in duodenal wall (DW) than in plasma during both periods (

Indexed as

metabolismoral bioavailabilityrabbitsself-emulsifying pelletsthymol

Identifiers

PMID41301947
PMCPMC12649353

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.